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November 19, 2022Oral diseases, while largely preventable, pose a major health burden for many countries and affect people throughout their lifetime, causing pain, discomfort, disfigurement and even death. It is estimated that oral diseases affect nearly 3.5 billion people. Untreated dental caries (tooth decay) in permanent teeth is the most common health condition according to the Global Burden of Disease 2019. Treatment for oral health conditions is expensive and usually not part of universal health coverage (UHC). Most low- and middle-income countries do not have sufficient services available to prevent and treat oral health conditions. Oral diseases are caused by a range of modifiable risk factors common to many noncommunicable diseases (NCDs), including sugar consumption, tobacco use, alcohol use and poor hygiene, and their underlying social and commercial determinants. Read more details at WHO (World Health Organization) Dental Implants may help if teeth are gone, but better they won´t get lost. Author(s) Source WHO 18.11.2022german comment This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
November 1, 2022From 2024, the Independent Patient Counseling Service (UPD) in Germany will no longer be run as a non-profit limited liability company but as a foundation under civil law. Ab 2024 wird die unabhängige Patientenberatung (UPD) in Deutschland nicht mehr als gemeinnützige GmbH sondern im Rahmen einer Stiftung bürgerlichen Rechts geführt. Despite funding by health insurers, the UPD is to operate independently. Also independently of the state and on an ongoing basis. It will be called “Stiftung Unabhängige Patientenberatung Deutschland (UPD)”. Information services are to be offered centrally and regionally. They should be low-threshold, citizen-oriented and barrier-free. A continuation or takeover of the structures of the previous UPD is not planned. Trotz der Finanzierung durch die Krankenversicherer soll die UPD unabhängig arbeiten. Sie soll staatsfern und kontinuierlich weiterge­führt werden. Sie wird „Stiftung Unabhängige Patientenberatung Deutschland (UPD)“ heißen. Informationsangebote sollen zentral und regional angeboten werden. Sie sollen niederschwellig, bürgernah und barrierefrei erreicht werden können. Eine Fortführung oder Übernahme der Strukturen der bisherigen UPD ist nicht vorgesehen. The fact that the planned legal form of a foundation is to be set up and financed by insurance companies – i.e. by the very organizations that very often trigger complaints and requests for advice from patients – is viewed critically. This would counteract the desired independence of the state. Kritisch wird gesehen, dass die geplante Rechtsform einer Stiftung durch Versicherungen eingerichtet und finanziert werden solle – also ausgerechnet von den Organisationen, die sehr häufig Auslöser von Beschwerden und Beratungsanliegen von Patienten seien. Damit würde die gewünschte Staatsferne konterkariert. Author(s) Source 1) bee/may/aerzteblatt.de 2) Andrick B 3) pr 1) aerzteblatt.de 20.10.20222) Vorschlag für einen Gesetzentwurf3) zm-online, 16.11.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 31, 2022In 2021 306,272 hip and knee replacements were recorded in the Endoprostheses Register Germany (EPRD). According to the report, the number of all documented knee interventions is eight percent below the comparable figures before the pandemic, while the number of hip interventions fell by just under one percent. Short stem and femoral neck prostheses together accounted for about 13 percent of fittings. However, at 32 hospitals, these stem types were used in more than half of the surgeries last year. The majority of hospitals chose full cementing for total knee arthroplasty in the vast majority of cases. 190 hospitals even implanted full-cement implants exclusively, and 81 other hospitals did so in more than 90 percent of cases. However, there were also 14 hospitals in which other types of anchorage predominated. According to the registry, the use of short stems is one of the trends in hip replacement care. They are now used in 12% of all hip implantations (6% the year before). There is a trend toward larger head components (36-mm heads were used in about 44 percent of cases, +3%). Author(s) Source © EB/aerzteblatt.de aerzteblatt.de, Endoprothesen­registerzeigt Versorgungs­unterschiede auf 31.10.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 29, 2022A computer screen shows the question “Would you like some water?” Underneath, three dots blink, followed by words that appear, one at a time: “No I am not thirsty.” It was brain activity that made those words materialize—the brain of a man who has not spoken for more than 15 years, ever since a stroke damaged the connection between his brain and the rest of his body, leaving him mostly paralyzed. We’re now pushing to expand to a broader vocabulary. To make that work, we need to continue to improve the current algorithms and interfaces, but I am confident those improvements will happen in the coming months and years. Now that the proof of principle has been established, the goal is optimization. We can focus on making our system faster, more accurate, and—most important— safer and more reliable. Things should move quickly now. Probably the biggest breakthroughs will come if we can get a better understanding of the brain systems we’re trying to decode, and how paralysis alters their activity. We’ve come to realize that the neural patterns of a paralyzed person who can’t send commands to the muscles of their vocal tract are very different from those of an epilepsy patient who can. We’re attempting an ambitious feat of BMI engineering while there is still lots to learn about the underlying neuroscience. We believe it will all come together to give our patients their voices back. Author(s) Source E Chang IEEE Spectrum, 29 Oct 2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 27, 2022Die Online-Plattform „Gesundheitsnavigator“ der deutschen Krankenversicherung AOK informiert jetzt darüber, welche Krankenhäuser bei kathetergestützten Aortenklappenimplantationen (transvaskulären Aortenklappenimplantationen, TAVI) besonders gute Behandlungsergebnisse vorweisen. Dafür können Ärzte und Patienten die Ergebnisse von 79 Kliniken abrufen, die in den Jahren 2018 bis 2020 eine solche TAVI bei knapp 23.000 Versicherten durchgeführt haben. Einer Analyse des Wissenschaftlichen Instituts der AOK (WidO) zufolge gab es im Viertel der Kliniken mit den besten Ergebnissen eine Gesamtkomplikationsrate von 5,1 Prozent. Im Viertel der Kliniken, die am schlechtes­ten abschneiden, liegt dieser Wert bei 7,1 Prozent. Die Auswertung zeigt zudem eine durchschnittliche Sterblichkeitsrate der behandelten Patienten von 2,8 Pro­zent. Im Viertel der Kliniken mit den besten Ergebnissen ist die Sterblichkeit nach TAVIs mit 2,1 Prozent nie­driger als im Viertel der schlechtesten Kliniken (3,8 Prozent). Auch bei der Häufigkeit von Herzinfarkten und Schlaganfällen innerhalb von 30 Tagen nach dem Eingriff gibt es Unterschiede: So erleiden im Viertel der Kliniken mit den besten Ergebnissen 1,8 Prozent der TAVI-Patien­ten innerhalb von 30 Tagen einen Schlaganfall, während es im schlechtesten Viertel 3,9 Prozent sind. Es lohne sich für einweisende Ärzte und betroffene Patienten, sich vorab über die Ergebnisse zur Behand­lungs­­qualität und über die Fallzahlen der Kliniken in ihrer Umgebung zu informieren, sagte die Vorstands­vorsitzende des AOK-Bundesverbandes, Carola Reimann. Author(s) Source anonymus aerzteblatt.de, 27 Oct 2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 17, 2022Endocarditis is an infectious disease of the inner lining of the heart (endocardium). It is frequently associated with severe progression (high morbidity) and often with a poor prognosis (high mortality). Therefore, antibiotics have been prescribed for prophylaxis in patients with a risk profile for endocarditis for more than 50 years. This antibiotic prophylaxis, which has been established for many years, aims to intercept bacteremia during invasive procedures in the oral cavity to reduce the risk of endocarditis. Single dose protocol: 30 – 60 minutes before the procedure: oral Amoxicillin not possible top take orally Ampicillin or Cefazolin or Ceftriaxone allergy to penicillin or ampicillin – oral Cefalexin or Azithromycin or Clarithromycin or Doxycyclin allergy to penicillin or ampicillin – no oral intake possible Cefazolin or Ceftriaxone Pay attention to exact dosage and instructions in the original article. According to the largely uniform recommendations of the American Heart Association in 2007 and the European Society of Cardiology in 2009, endocarditis prophylaxis should only be used in patients who belong to the following risk groups: survived endocarditis artificial heart valves patients with the following congenital heart defects: a) non-treated heart defects b) treated heart defects with residual defects c) heart defects repaired with artificial material after heart transplantation Author(s) Source Bilobrk P, Grötz KA ZZI 3/2022, DOI.org/10.53180/ ZZI.2022.0142–0144 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 12, 2022Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease. However, organoids lack the connectivity that exists in vivo, which limits maturation and makes integration with other circuits that control behaviour impossible. Here we show that human stem cell-derived cortical organoids transplanted into the somatosensory cortex of newborn athymic rats develop mature cell types that integrate into sensory and motivation-related circuits. MRI reveals post-transplantation organoid growth across multiple stem cell lines and animals, whereas single-nucleus profiling shows progression of corticogenesis and the emergence of activity-dependent transcriptional programs. Indeed, transplanted cortical neurons display more complex morphological, synaptic and intrinsic membrane properties than their in vitro counterparts, which enables the discovery of defects in neurons derived from individuals with Timothy syndrome. Anatomical and functional tracings show that transplanted organoids receive thalamocortical and corticocortical inputs, and in vivo recordings of neural activity demonstrate that these inputs can produce sensory responses in human cells. Finally, cortical organoids extend axons throughout the rat brain and their optogenetic activation can drive reward-seeking behaviour. Thus, transplanted human cortical neurons mature and engage host circuits that control behaviour. We anticipate that this approach will be useful for detecting circuit-level phenotypes in patient-derived cells that cannot otherwise be uncovered. Author(s) Source Revah O, Gore F, Kelley KW et al. Nature volume 610, 319–326 (2022) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 30, 2022The Zygoma implant was originally introduced by Brånemark in 1989 for the oral rehabilitation of patients who had undergone maxillectomy. It later evolved into an alternative treatment to avoid more extensive bone augmentations prior to masticatory rehabilitation of edentulous atrophic maxillae. This approach represents an adequate stabilization system in which the prosthetic provisional can provide additive implant stabilization immediately after surgery. However, given the anatomical characteristics of zygomatic processes and limited intraoperative visibility, surgical complications during zygoma implant placement – especially when multiple, adjacent zygoma implants are placed – often pose some challeng In the restoration of the atrophic maxilla, zygoma implants represent an option at least equivalent to two-stage restorations (augmentation and implant placement) with high survival rates and a low number of complications. Affected patients should also be informed about this option Author(s) Source Kämmerer PW, Fan S, Bjelopavlovic M, Kraus A, Sagheb K, Schiegnitz E ZZI 3/2022, DOI: 10.53180/ZZI.2022.0146–0150 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 13, 2022A research group from the Göttingen Cluster of Excellence Multiscale Bioimaging is working on an optogenetic cochlear implant (oCI). Electric cochlear implants (eCIs) are used by more than one million people worldwide and enable those affected to understand speech in a quiet environment. But those affected are known to have difficulty understanding speech in background noise, interpreting the emotional tone of speech, or enjoying melodies in music. Therefore, according to researchers, there is a great clinical need to improve hearing with CI. By combining an optical CI with gene therapy, they hope to achieve a fundamental improvement in frequency resolution. Gene therapy is used to introduce a light-activated ion channel into spiral ganglion neurons of the cochlea and make them light-sensitive. According to the team, what has already been successful in animal models now needs to be further developed for use in humans. The planned 64-channel optical CI should enable users to understand speech even in noisy environments, recognize speech melodies and enjoy melodies.Moser and his team have already provided preclinical proof of concept for gene therapy of the cochlea and for the optical CI as a new medical device. However, there is still a considerable need for research before the planned start of a first clinical trial in 2026, the group said. Author(s) Source hil/aerzteblatt.de dtsch aerzteblatt 13.09.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 9, 2022After a transient ischemic attack (TIA) or stroke, clinically stable patients do not appear to benefit from treatment with a stent. However, this may not be true for high-risk patients. This is shown by a Chinese-American study now published in the Journal of the American Medical Association (JAMA) (DOI: 10.1001/jama.2022.12000). The results of the new study confirm those of studies published eight years ago: In patients with intracranial stenoses who are in a clinically stable condition, stents provide no additional benefit. An indication for stent implantation is seen in patients with intracranial stenosis with a degree of stenosis of at least 70 percent who have suffered at least one further infarction after a stenosis-related infarction despite subsequent intensive drug therapy. “Not treating affected patients with progressive neurological symptoms at all because of a lack of data and waiting until a subsequent event occurs still seems questionable to us” (Diener). What is needed, on the other hand, is more precise patient selection so that those affected can receive therapy in a timely manner, the expert said. “A second event should be prevented and not waited for as an indication criterion” (P Berlit). Author(s) Source hil/aerzteblatt.de aerzteblatt.de 09.09.2022 (german) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 8, 2022The U.S. Food and Drug Administration (FDA) is informing the public about reports of cancers, including squamous cell carcinoma (SCC) and various lymphomas, in the scar tissue (capsule) that forms around breast implants. The various lymphomas reported are not the same as the lymphomas described in previous FDA Communications as Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). After preliminary review of published literature as part of our ongoing monitoring of the safety of breast implants, the FDA is aware of less than 20 cases of SCC and less than 30 cases of various lymphomas in the capsule around the breast implant. As of September 1, 2022, the FDA has received 10 medical device reports (MDRs) about SCC related to breast implants and 12 MDRs about various lymphomas related to breast implants. While the FDA believes that occurrences of SCC or various lymphomas in the capsule around the breast implant may be rare, health care providers and people who have or are considering breast implants should be aware that cases have been reported to the FDA and in the literature. Currently, the incidence rate and risk factors for SCC and various lymphomas in the capsule around the breast implants are unknown. This is an emerging issue and our understanding is evolving. For this reason, the FDA is asking health care providers and people with breast implants to report cases of SCC, lymphomas, or any other cancers around the breast implant to the FDA. Author(s) Source FDA FDA, 08.09.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
August 29, 2022The complaint was filed by a 52-year-old woman, who had already undergone breast augmentation with saline implants at the age of 26. When she visited her gynecologist because of a leaking implant, he diagnosed breast cancer – both implants had to be removed. Two years after the operation, she applied for a new breast augmentation, according to the regional social court, citing psychological stress. She could not be expected to be satisfied with a situation that did not correspond to the aesthetics of the female body. The Regional Social Court now confirmed the opinion of the health insurance company: In the case of the plaintiff, there was neither an impairment of a bodily function nor a disfiguring anatomical deviation. A subjective burden due to the appearance could not justify an intervention, the court ruled – also because of the difficulties of predicting the psychological effects of physical changes. Author(s) Source dpa/aerzteblatt.de aerzteblatt de, 29.08.2022, State Social Court of Lower Saxony-Bremen, file no.: L 16 KR 344/21 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
August 22, 2022Background Randomized controlled trials (RCTs) that are highly restrictive in terms of study design, with highly selected participants and conditions, produce results whose applicability to routine clinical care and usefulness for reimbursement decisions is sometimes questioned. Objectives In view of the background mentioned above, do more pragmatic RCTs and registry-based RCTs offer potential solutions? What are the opportunities and risks associated with more pragmatic studies and which methodological aspects should be given special attention? Results Clinical RCTs for comparative effectiveness evaluation are located on a continuum from “very pragmatic” to “very explanatory”. No consented threshold exists from which an RCT is considered pragmatic. More pragmatic RCTs are often characterized by less selected but larger patient groups, embedding into a normal care setting, and patient-relevant outcomes. They usually dispense with longer-term assurance of patient adherence to the initially assigned treatment, blinding, and resource intensive intermediate examinations. However, this can lead to problems in interpretation, especially if no differences between interventions are shown. Conclusions More pragmatic RCTs and registry-based RCTs have the potential to become an important basis for decision-making in clinical practice, but also for health policy and reimbursement issues. However, in order to realize this potential, a number of hurdles – especially legal ones – have to be abolished. Author(s) Source Lange S, Lauterberg J Prävention und Gesundheitsförderung (2022) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
August 10, 2022Aim To present the 20-year clinical outcomes of tissue-level implants in partially edentulous patients previously treated for periodontitis and in periodontally healthy patients (PHP). Material and Methods The original population consisted of 149 partially edentulous patients consecutively enrolled in a private specialist practice and divided into three groups: PHP, moderately periodontally compromised patients (mPCP) and severely PCP (sPCP). After successful completion of periodontal/implant therapy, patients were enrolled in an individualized supportive periodontal care (SPC) programme. Results Eighty-four patients rehabilitated with 172 implants reached the 20-year examination. During the observation time, 12 implants were removed (i.e., 11 due to biological complications and 1 due to implant fracture), leading to an overall implant survival rate of 93% (i.e., 94.9% for PHP, 91.8% for mPCP and 93.1% for sPCP). At 20 years, PCP compliant with SPC did not present with significantly higher odds of implant loss compared with PHP compliant with SPC. Conversely, PCP not compliant with SPC experienced implant loss with odds ratio of 14.59. Conclusions Tissue-level implants, placed after comprehensive periodontal therapy and SPC, yield favourable long-term results. However, patients with a history of periodontitis and non-compliant with SPC are at higher risk of biological complications and implant loss. Author(s) Source A Roccuzzo, J-C Imber, C Marruganti, GE Salvi, G Ramieri, M Roccuzzo J of Clin Periodontology, 10 Aug 2022, https://doi.org/10.1111/jcpe.13716 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
June 30, 2022Soft, bioresorbable coolers for reversible conduction block of peripheral nervesReeder et al. developed a soft, miniaturized, implantable cooler to temporarily block nerve conduction using a liquid-to-gas phase transition as the cooling mechanism (see the Perspective by Jiang and Hong). They borrowed the design of electrical nerve cuff and substituted electrical wires with a microfluidic channel carrying a microliter volume of bioinert coolant. A thermal thin-film sensor integrated within the cuff enabled monitoring of the temperature in real time, thus enabling closed-loop control. Implantable devices capable of targeted and reversible blocking of peripheral nerve activity may provide alternatives to opioids for treating pain. Local cooling represents an attractive means for on-demand elimination of pain signals, but traditional technologies are limited by rigid, bulky form factors; imprecise cooling; and requirements for extraction surgeries. Here, we introduce soft, bioresorbable, microfluidic devices that enable delivery of focused, minimally invasive cooling power at arbitrary depths in living tissues with real-time temperature feedback control. Construction with water-soluble, biocompatible materials leads to dissolution and bioresorption as a mechanism to eliminate unnecessary device load and risk to the patient without additional surgeries. Author(s) Source Reeder JT, Xie Z, Yang Q et al. SCIENCE, 30 Jun 2022, Vol 377, Issue 6601, pp. 109-115 DOI: 10.1126/science.abl8532 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
June 30, 2022Younger patients who receive an implantable defibrillator are significantly less likely than older defibrillator patients to suffer from CHD and extracardiac comorbidities. They also have a better ejection fraction, 42% versus 32%. However, they are twice as likely (16.4% versus 8.2%) to come in for revision because of device-associated complications than older patients S Hakmi, D-U Chun, Hamburg, Germany, DGK Annual Congress 2022, DEVICE Registry). The registry prospectively enrolled a total of 4181 patients from 50 centers in Germany between 2007 and 2011 who had received implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy with defibrillator (CRT-D). While heart failure was the most common reason for presentation in older patients, survived cardiac death, hypertrophic cardiomyopathies, and primary electrical heart disease dominated in younger patients. The 1-year mortality was lower in the young patients than in older patients, 3.1 versus 7.3%, respectively. Cardiologists attributed the higher complication rate to the greater activity of younger patients. Author(s) Source SuK Deutsches Ärzteblatt Dtsch Ärztebl 2022; 119(24): 4 (german) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
June 28, 2022A 57-year-old man with nonischemic cardiomyopathy who was dependent on venoarterial extracorporeal membrane oxygenation (ECMO) and was not a candidate for standard therapeutics, including a traditional allograft, received a heart from a genetically modified pig source animal that had 10 individual gene edits. Sudden diastolic thickening and failure of the xenograft occurred on day 49 after transplantation, and life support was withdrawn on day 60. On autopsy, the xenograft was found to be edematous, having nearly doubled in weight. Histologic examination revealed scattered myocyte necrosis, interstitial edema, and red-cell extravasation, without evidence of microvascular thrombosis — findings that were not consistent with typical rejection. Studies are under way to identify the mechanisms responsible for these changes. (Funded by the University of Maryland Medical Center and School of Medicine.) Author(s) Source Griffith BP, Goerlich CE, Singh AK, Rothblatt M et al. The New England Journal of Medicine, June 22, 2022, DOI: 10.1056/NEJMoa2201422 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
June 2, 2022tympanic membrane: Textile researchers at TU Dresden have developed a novel drumhead implant made of fibers. In tests conducted by the developers, the bioinspired innovation performed significantly better than conventional implants. The textile membrane enables a complete, permanent and lifelike reconstruction of the eardrum (D Aibibu). Tests have shown that the textile replacement eardrum has the same vibration characteristics as a real eardrum. Materials are polycaprolactone, a biodegradable plastic, and silk fibroin, a protein extracted from the cocoons of silkworms. Using an electrospinning process, which is also used to make stents for regenerative medicine, very fine threads are drawn from this protein-plastic solution and laid down to form a textile replacement eardrum. hip endoprosthesis: hip endoprosthesis can become loose and make revision require revision surgery. An endoprosthesis with a three-dimensional textile structure made of ceramic is being developed for this purpose. The material used also resembles hydroxyapatite. Author(s) Source Innomedia med engeneering 02.06.2022 (german) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
April 28, 2022While the manufacturing of biological tissue meets major societal demands, it also faces significant challenges related to process standardization and scaling up. With these challenges in mind, the French start-up Poietis has developed the Next Generation Bioprinting (NGB) platform to achieve 4D bioprinting of biological tissue in a faster, more affordable and more functional way. Fabien Guillemot: First of all, the benefit is to make treatments more affordable for patients because currently a bioprinted cornea is marketed at a price of around 100,000 euros. Despite the immense benefit to patients, it is difficult for health care systems to bear this cost. There is therefore a challenge to reduce manufacturing costs to make these strategies both clinically effective and affordable. The other benefit is to increase the functionality of the biological tissue by deciding on the composition and architecture of what’s implanted. It has been demonstrated that controlling the architecture of tissue makes it more functional…. With our platform, we are able to manufacture a dermal-epidermal substitute. Author(s) Source Celia Sampol E-Magazine, 28.04.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
April 4, 2022Where standard 3D printing uses a digital blueprint to manufacture an object out of materials like plastic or resin, 3D bioprinting manufactures biological parts and tissues out of living cells, or bioinks. A fourth dimension — shape transformation over time — can be achieved by incorporating materials that enable printed constructs to morph multiple times in a preprogrammed or on-demand manner in response to external signals. Bioprinting 4D constructs provides opportunities for scientists to better mimic the shape changes that occur during the development, healing and normal function of real tissues and fabricate complex structures. This bioink system provides the opportunity to print bioconstructs capable of achieving more sophisticated architectural changes over time than was previously possible. These cell-rich structures with pre-programmable and controllable shape morphing promise to better mimic the body’s natural developmental processes and could help scientists conduct more accurate studies of tissue morphogenesis and achieve greater advances in tissue engineering,” said study corresponding author Eben Alsberg Author(s) Source Carey J University of Illinois Chicago, 04.04.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
March 25, 2022Extensive surgical experience in the area of unicondylar sled prosthesis of the knee reduces the risk of further interventions. This is the result of an analysis conducted by the Institute for Quality and Efficiency in Health Care (IQWiG, Germany). However, the only robust study provided data only on revision risk. The relationship between service volume and treatment quality with a view to the physician level and other relevant target variables was not investigated. It is based on AOK billing data, which only provides results on the influence of the volume of services per hospital on the revision rate within five years after the first intervention and shows: The higher the volume of procedures per hospital, the fewer revisions are necessary. The data do not allow any deductions to be made about hospital and physician characteristics or relevant outcome measures of morbidity (for example, prosthesis loosening or instability of the knee joint, fractures, pain, or joint infections) or health-related quality of life (mobility and independence). Author(s) Source hil/sb/aerzteblatt.de aerzteblatt.de, 25.03.2022 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
March 24, 2022Ceramic implants establish in modern dental implantology as a supplement to the treatment spectrum with titanium implants. An increasing interest can be observed not only on the part of health-conscious patients, but also in the dental profession due to the biological advantages. The large number of participants in an extensive survey alone shows the interest in the topic of ceramic implants in dentistry and oral surgery. The possible advantages of the material zirconia dioxide in terms of biocompatibility and low tendency to inflammation were confirmed and are in line with our view. In particular, a significantly lower tendency to periimplantitis seems to be observed in free practice, which should be confirmed by the initialization of corresponding clinical studies. The fear of the past regarding stability could at least be relativized for the newer systems since fractures are not in the foreground in the data on the reasons for loss. The potential for osseointegration was rated equally for both materials. In particular, the proportionally most frequently mentioned “early loss” during the healing phase gives cause for further evaluation. Since various factors such as overloading, incorrect loading, surface design, bone degeneration due to overheating can play a role, further differentiation should be made here in order to reduce failures. All responses indicate a clear tendency towards two-part systems, which allow a broader range of indications and offer more flexibility. Solutions are requested which simplify the application compared to titanium implants. Author(s) Source Chen A, Chevalier J, Fischer J et al. ESCI – European Society for Ceramic Implantology, 24.03.2022 german: klinische Anwendung von Keramikimplantaten This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
March 22, 2022Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means of communication. While others have evaluated communication in people with remaining muscle control, to the best of our knowledge, it is not known whether neural-based communication remains possible in a completely locked-in state. Here, we implanted two 64 microelectrode arrays in the supplementary and primary motor cortex of a patient in a completely locked-in state with ALS. The patient modulated neural firing rates based on auditory feedback and he used this strategy to select letters one at a time to form words and phrases to communicate his needs and experiences. This case study provides evidence that brain-based volitional communication is possible even in a completely locked-in state. Author(s) Source Chaudhary U, Vlachos J, Zimmermann JB et al. Nature Communications volume 13, Article number: 1236 (2022)  This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
March 19, 2022Typically, manufacturing technology is done in four steps: creating or scanning, converting to a file, specifying the print material, and manufacturing. The production of artificial tissues using 3D printing is known as bioprinting. The most common method is the top-down approach. Recently, the bottom-up proceeding has also been successful. Certain requirements apply to the materials used for printing, which are described in more detail in the article. The Vat-polymerisation uses liquid, photosensitive polymers, which are hardened layer by layer by means of a UV light source. Multi-Jet Modeling uses individual, variably connectable pressure nozzles for the ejection of the droplet-shaped print material. The methodology of in-situ bioprinting, in which the desired tissue is printed directly into the patient’s tissue defect, shows great potential. Bioprinting could completely revolutionize large parts of modern medicine in the near future. Author(s) Source Pantermehl S, Emmert S, Alkildani S, Foth A, Jung O, Barbeck M Oralchirurgie Journal 1/2022, 14-18, (german original, Oemus Verlag) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
March 7, 2022Comparison of Long-term Performance of Bioprosthetic Aortic Valves in Sweden From 2003 to 2018 Importance  The performance of bioprosthetic aortic valves is usually assessed in single valve models or head-to-head comparisons. National databases or registries offer the opportunity to investigate all available valve models in the population and allows for a comparative assessment of their performance. Objective  To analyze the long-term rates of reintervention, all-cause mortality, and heart failure hospitalization associated with commonly used bioprosthetic aortic valves and to identify valve model groups with deviation in clinical performance. Results  A total of 16 983 patients (mean age, 72.6 years; 10 685 men ) were included in the analysis. The Perimount valve model group had the lowest and the Mitroflow/Crown valve model group had the highest cumulative incidence of reintervention. The estimated cumulative incidence of reintervention at 10 years was 3.6% (95% CI, 3.1%-4.2%) in the Perimount valve model group and 12.2% (95% CI, 9.8%-15.1%) in the Mitroflow/Crown valve model group. The estimated incidence of reintervention at 10 years was 9.3% (95% CI, 7.3%-11.3%) in the Soprano valve model group.Conclusions and Relevance  Results of this study showed that the Perimount valve was the most commonly used and had the lowest incidence of reintervention, all-cause mortality, and heart failure hospitalization, whereas the Mitroflow/Crown valve had the highest rates. These findings highlight the need for clinical vigilance in patients who receive either a Soprano or Mitroflow/Crown aortic bioprosthesis. Author(s) Source Persson M, Glaser N, Nilsson J et al. JAMA Netw Open. 2022;5(3):e220962. doi:10.1001/jamanetworkopen.2022.0962 german translation: Bio-Aortenklappen halten unterschiedlich lange aerzteblatt.de 08.03.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
March 2, 2022Ten years after its launch, the Endoprosthesis Register Germany (EPRD) has now surpassed the two-million mark in the recording of surgical documentation. This can be a reliable database for assessing hip and knee endoprosthetic care in Germany. The voluntary data supplied by more than 780 hospitals cover more than 70 percent of care in Germany. Within a very short time, the EPRD has thus grown to become the second largest endoprosthetic registry in Europe. “The clinics’ participation in the EPRD has become a quality feature for patients. The hospital thus shows that it works transparently, is open to comparison with other hospitals and, above all, is interested in the best possible results.” a spokesman says. A special feature of the EPRD is the collaboration with the British National Joint Registry (NJR). The two registries have developed standards for their databases – these are intended to serve internationally as a blueprint endoprosthetic registries Author(s) Source EB/aha/aerzteblatt.de dtsch aerzteblatt.de 02.03.2022, german original This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 16, 2022Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs A major challenge in lung transplantation is the need for ABO blood group matching. To address this challenge, Wang et al. used two enzymes, FpGalNAc deacetylase and FpGalactosaminidase, to convert blood group A lungs to blood group O lungs during ex vivo lung perfusion. The authors demonstrated successful removal of blood group A antigen with no overt changes in lung health. In an ex vivo simulation of transplantation, the authors showed reduced antibody and complement deposition, suggesting that this technique may reduce antibody-mediated injury in vivo. Together, these findings have the potential to improve fairness in lung allocation for transplantation. The treatment of donor lungs minimized antibody binding, complement deposition, and antibody-mediated injury as compared with control lungs. These results show that depletion of donor lung A-Ag can be achieved with EVLP treatment. This strategy has the potential to expand ABO-incompatible lung transplantation and lead to improvements in fairness of organ allocation. Author(s) Source Wang A, Ribeiro RV, Ali A et al. SCIENCE TRANSLATIONAL MEDICINE • 16 Feb 2022 • Vol 14, Issue 632 • DOI: 10.1126/scitranslmed.abm7190 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...