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March 1, 2023Berlin – Health researchers are expecting progress from the EU Commission’s initiative for cross-border use of medical data. Health researcher Ferdinand Gerlach of the University of Frankfurt am Main highlighted the practical benefits of a European Health Data Space. It is a matter of life and health if physicians throughout Europe have access to medical data, including that of foreign patients, he said. The effective transfer of this information is important, for example, in the case of identified drug risks. Patients with rare diseases in particular benefit from the European Health Data Area, Gerlach added. This is because there are often not enough cases for research. The benefits of an EHDS are large and concrete, he said. Christof von Kalle of the Berlin Institute for Health Research at the Charité said it is about data spaces over which patients have power of disposal, but which must also be complete. In addition, the software products used must be designed to be interoperable. Manufacturers should be obliged to offer such transition points at no additional cost. Cryptography expert Dominique Schröder of the University of Erlangen-Nuremberg asserted that the processing of large amounts of data does not conflict with privacy and data protection. In the EU project, IT security should be involved from the beginning. Data protection law expert Fruzsina Molnar-Gabor of the Heidelberg Academy of Sciences also advocated the broad availability of health-related data. However, high data protection requirements would also have to be met. The EU is currently a long way from digital networking and interoperability, the data systems are too different and not linked nationally, she said. Marcel Weigand of the Independent Patient Counseling Service (UPD) spoke of a significant initiative in favor of patient care, according to the Bundestag. Already today, cross-border health services are available in several EU countries. Germany, on the other hand, is lagging behind and needs to catch up. Larger data volumes would also bring advantages in healthcare research. What is needed, however, are security, reliability and transparency. Author(s) Source © EB/aerzteblatt.de aerzteblatt.de 01.03.2023 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 20, 2023Cerebral strokes can disrupt descending commands from motor cortical areas to the spinal cord, which can result in permanent motor deficits of the arm and hand. However, below the lesion, the spinal circuits that control movement remain intact and could be targeted by neurotechnologies to restore movement. Here we report results from two participants in a first-in-human study using electrical stimulation of cervical spinal circuits to facilitate arm and hand motor control in chronic post-stroke hemiparesis. We found that continuous stimulation through selected contacts improved strength, kinematics and functional movements, thereby enabling participants to perform movements that they could not perform without spinal cord stimulation. While we cannot conclusively evaluate safety and efficacy from two participants, our data provide promising, albeit preliminary, evidence that spinal cord stimulation could be an assistive as well as a restorative approach for upper-limb recovery after stroke. Author(s) Source Powell MP, Verma N, Sorensen E et al. Nat Med (2023). https://doi.org/10.1038/s41591-022-02202-6 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
and hearing aid provision in the
Gutenberg Health Study">February 17, 2023Hearing is a basic skill needed to participate in daily life. Hearing loss therefore often significantly limits the quality of life. Nevertheless, there are hardly any epidemiological data on the prevalence of hearing disorders in Germany. The study examined the prevalence of hearing impairment and the actual provision of hearing aids. In total, tonaudiometric data from 5 024 participants could be analyzed. The prevalence of hearing loss in at least one ear, regardless of severity, was 40.6% in the study population. Low-grade hearing loss was found in 22.5% of the participants, moderate hearing loss in 8.3%, and profound hearing loss in 2.8% (classification according to Röser from 1973). The hearing ability of women was better than that of men (on average by 4.3 dB). An increased prevalence of hearing impairment was seen with increasing age. Only 7.7% of participants had bilateral hearing aids. The discrepancy between the prevalence of hearing loss and the indication for hearing aid fitting results from the different ways in which hearing loss is determined and the indication is made. Conclusion: The prevalence of hearing loss was high at 40.6%. For the general population in Germany, regular hearing tests should be recommended from the age of 60 at the latest. Author(s) Source Döge J, Hackenberg B, O‘Brien K, Bohnert A, Rader T, Beutel ME, Münzel T, Pfeiffer N, Nagler M, Schmidtmann I, Wild PS, Matthias C, Bahr K Dtsch Arztebl Int 2023; 120: 99–106. DOI: 10.3238/arztebl.m2022.0385 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 2, 2023The healthcare sector needs digitization, that is undisputed. The focus of the public debate so far has been on efficiency gains and cost savings, as well as data-driven improvements in care. The potential is enormous, because digitization creates resilience and strengthens Europe’s economic sovereignty, and – most importantly – it can cushion the industry’s biggest problem: Staff shortages. Digital innovations offer the only chance to defuse this problem, which has not yet reached the public’s awareness clearly enough. Because speed in digitization is no longer a desirable goal, but a bitter necessity. The focus will have to shift to innovations that increase efficiency and thus save resources. In particular, the automation of documentation can free up personnel to a considerable extent. So it is specifically about data-driven innovation. However, access to health data by academic players and the resulting scientific publications will hardly help. Only speed and short development cycles can help – and these can only be achieved through competition and industrial solutions. Legal certainty and clear guidelines for the use of data are essential prerequisites for innovation. At the moment, however, we are seeing exactly the opposite, with the EU Commission presenting new regulations at an unprecedented pace: The Data Governance Act, the Data Act, the AI Regulation, and the European Health Data Space Regulation (“EHDS-VO-E”). Many of these regulations are being discussed in parallel at the European and national levels. As a result, it is difficult for most companies in the industry to imagine in concrete terms what these regulations might mean in practice for their own business. The following aspects of the draft are particularly critical: 1. citizens are literally disenfranchised, and the right to informational self-determination is lost. The scope of the consent-free secondary use of data is tantamount to a complete loss of control by those affected. 2. If this data is nationalized, a kind of data socialism is created. This is because the regulation created an obligation for companies to provide all health data to so-called “access points.” The obligation to disclose all data collected in primary use destroys the motivation to gain an edge, for example, in publishing research results, through the cost-intensive collection of particularly good and structured data – this inevitably weakens Europe as a business location. 3. The greatest danger is that the dystopia of the “transparent citizen” will come true. Despite the ban, re-identification cannot be ruled out and the privacy of those affected is at risk, because data leaks basically provide everyone with the necessary profiles for re-identification – and large platform companies have access to quite a bit of personal data anyway. Initially anonymized and basically pseudonymized individual data records can often be reassigned to the original persons by linking them with other data records. The broad provision of anonymized and pseudonymized individual data records envisaged by the draft regulation is therefore problematic. The problem of anonymized data sets Anonymization of health data describes the process by which the personal parts of a data record, which are usually sensitive and worthy of protection, are removed or changed. This ensures that they can no longer be assigned to the specific person, or only with disproportionate effort. This forms the basis of the secondary use of health data and pursues the goal of protecting the privacy of patients and preventing misuse. Anonymization can be reversed by selectively linking different data sets – so-called re-identification. The problem is not limited to the healthcare industry. A specific case arose in 2007, for example, when Netflix published ten million movie rankings. Although these were anonymized and identifying data was replaced by random numbers, researchers managed to de-anonymize parts of the dataset by matching them with rankings and their timestamps from other movie websites – personal data was revealed. Preventing the creation of user profiles is difficult given the complexity of the systems and algorithms used. In addition, it is difficult to prove illegal use of data or violations of competition law. Legal measures introduced subsequently have been ineffective to date because the massive networking of different areas of life has created dependencies that make subsequent unbundling impracticable. (editorially abridged) Author(s) Source Vilsmeier S (CEO of Brainlab AG) FAZ 28.02.2023 (“Digitalisierung Europas: Wie die EU-Kommission Gesundheitsdaten verstaatlicht (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
Implantable Defibrillator System Shock Function, Mortality, and Cause of Death After Magnetic Resonance Imaging">January 31, 2023Studies have shown that magnetic resonance imaging (MRI) does not have clinically important effects on the device parameters of non–MRI-conditional implantable cardioverter-defibrillators (ICDs). However, data on non–MRI-conditional ICD detection and treatment of arrhythmias after MRI are limited. During a median follow-up of 2.2 years from MRI to latest available ICD interrogation before generator or lead exchange in 536 patients, 4177 arrhythmia episodes were detected, and 97 patients received ICD shocks. Sixty-one patients (10% of total) had 130 spontaneous ventricular tachycardia or fibrillation events terminated by ICD shocks. A total of 210 patients (33% of total) are known to have died (median, 1.7 years from MRI to death); 3 had cardiac arrhythmia deaths where shocks were indicated without direct evidence of device dysfunction. Conclusion: Non–MRI-conditional ICDs appropriately treated detected tachyarrhythmias after MRI. No serious adverse effects on device function were reported after MRI. Author(s) Source Ra J, Oberdier MT, Suzuki M et al. Annals of Internal Medicine, 31.Jan 2023, https://doi.org/10.7326/M22-2653 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
January 30, 2023Medical devices such as insulin pumps, defibrillators and brain stimulators are getting more and more connectivity. As more and more patients receive implants to treat conditions ranging from diabetes and Parkinson’s disease to deafness and heart failure, implants are becoming more complex – and thus more wirelessly controllable. This means that smartphones could soon be able to manage devices such as pacemakers and insulin pumps very easily and conveniently. The therapy method from the field of functional neurosurgery is called deep brain stimulation (DBS). It involves sending electrical impulses to the brain to relieve symptoms of Parkinson’s disease, chronic pain, depression, tremors or other medical disorders. Once these devices are connected to the Internet, they can give rise to threats known as “brainjacking.” If an attacker then succeeds in cracking a device’s previously inadequate security measures, he has several options for manipulating his victim’s implant. In this way, hackers are able to control a person’s behavior. Since neurostimulators currently cannot provide reliable security, a secure communication channel between the device programmer and the neurostimulator must be established. This can be achieved with a shared session key and symmetric encryption. Two major challenges need to be addressed: Generation of the session key. Secure transmission of the session key to the other party. It is also helpful to have a low transmission power, which can only be received when there is direct contact. Author(s) Source Geißler O Security Insider 30.01.2023 (german) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
January 21, 2023Speech brain-computer interfaces (BCIs) have the potential to restore rapid communication to people with paralysis by decoding neural activity evoked by attempted speaking movements into text or sound.Early demonstrations, while promising, have not yet achieved accuracies high enough for communication of unconstrainted sentences from a large vocabulary. Here, we demonstrate the first speech-to-text BCI that records spiking activity from intracortical microelectrode arrays. Finally, we highlight two aspects of the neural code for speech that are encouraging for speech BCIs: spatially intermixed tuning to speech articulators that makes accurate decoding possible from only a small region of cortex, and a detailed articulatory representation of phonemes that persists years after paralysis. These results show a feasible path forward for using intracortical speech BCIs to restore rapid communication to people with paralysis who can no longer speak. Author(s) Source Willett F, Kunz E, Avansino D et al. bioRχiv Jan 21, 2023, doi: https://doi.org/10.1101/2023.01.21.524489 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
January 13, 2023Interim Safety Profile From the Feasibility Study of the BrainGate Neural Interface SystemBrain computer interfaces (BCIs) are being developed to restore mobility, communication, and functional independence to people with paralysis. Though supported by decades of preclinical data, the safety of chronically implanted microelectrode array BCIs in humans is unknown. We report safety results from the prospective, open-label, non-randomized BrainGate feasibility study (NCT00912041), the largest and longest-running clinical trial of an implanted BCI. Results: From 2004 – 2021, fourteen adults enrolled in the BrainGate trial had devices surgically implanted. The average duration of device implantation was 872 days, yielding 12,203 days of safety experience. There were 68 device-related adverse events, including 6 device-related serious adverse events. The most common device-related adverse event was skin irritation around the percutaneous pedestal. There were no safety events that required device explantation, no unanticipated adverse device events, no intracranial infections, and no participant deaths or adverse events resulting in permanently increased disability related to the investigational device. Discussion: The BrainGate Neural Interface system has a safety record comparable to other chronically implanted medical devices. Given rapid recent advances in this technology and continued performance gains, these data suggest a favorable risk/benefit ratio in appropriately selected individuals to support ongoing research and development. Author(s) Source Rubin DB, Ajiboye AB, Barefoot L et al. Neurology.org, January 13, 2023, DOI: https://doi.org/10.1212/WNL.0000000000201707 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis">December 31, 2022End-stage ankle osteoarthritis causes severe pain and disability. There are no randomized trials comparing the 2 main surgical treatments: total ankle replacement (TAR) and ankle fusion (AF). Between 6 March 2015 and 10 January 2019, a total of 303 patients were randomly assigned. At 52 weeks, the scores improved for both groups. The adjusted difference showed that TAR improved more than AF, but the difference was not considered clinically or statistically significant. The number of adverse events was similar between groups, but there were more wound healing issues in the TAR group and more thromboembolic events and nonunion in the AF group. The symptomatic nonunion rate for AF was 7%. A post hoc analysis suggested superiority of fixed-bearing TAR over AF. Author(s) Source Goldberg AJ, Chowdhury K, Bordea E et al. Annals of Internal Medicine, 12-2022, https://doi.org/10.7326/M22-2058 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 21, 2022Study identifies neurons that can improve sound perception, which could explain the variation in performance in people with cochlear devices. Stimulating neurons that are linked to alertness helps rats with cochlear implants learn to quickly recognize tunes, researchers have found. The results suggest that activity in a brain region called the locus coeruleus (LC) improves hearing perception in deaf rodents. Researchers say the insights are important for understanding how the brain processes sound, but caution that the approach is a long way from helping people. Cochlear implants use electrodes in the inner-ear region called the cochlea, which is damaged in people who have severe or total hearing loss. The device converts acoustic sounds into electrical signals that stimulate the auditory nerve, and the brain learns to process these signals to make sense of the auditory world. Some people with cochlear implants learn to recognize speech within hours of the device being implanted, whereas others can take months or years. “This problem has been around since the dawn of cochlear implants, and it shows no signs of being resolved” (Gerald Loeb, USCLA). Researchers caution that stimulating the LC in humans could be dangerous. The region sends signals to many brain regions, and regulates the fight-or-flight response. Stimulating the LC in people “would raise blood pressure and heart rate, and other autonomic responses”, says Graeme Clark, an otolaryngologist in the Graeme Clark Institute at the University of Melbourne, Australia, who developed the first multi-channel cochlear implant in the 1970s. “We would have to do a series of experiments to prove that it is something worth doing.” Author(s) Source Naddaf M nature, 21 Dec 2022doi: https://doi.org/10.1038/d41586-022-04553-z This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 21, 2022Cochlear implants (CIs) are neuroprosthetic devices that can provide hearing to deaf people. Despite the benefits offered by CIs, the time taken for hearing to be restored and perceptual accuracy after long-term CI use remain highly variable. CI use is believed to require neuroplasticity in the central auditory system, and differential engagement of neuroplastic mechanisms might contribute to the variability in outcomes. Despite extensive studies on how CIs activate the auditory system, the understanding of CI-related neuroplasticity remains limited. One potent factor enabling plasticity is the neuromodulator noradrenaline from the brainstem locus coeruleus (LC). Here we examine behavioural responses and neural activity in LC and auditory cortex of deafened rats fitted with multi-channel CIs. Adequate engagement of central neuromodulatory systems is thus a potential clinically relevant target for optimizing neuroprosthetic device use. Author(s) Source Glennon E Valtcheva S, Zhu A, et al. Nature volume 613, pages317–323 (2023), https://doi.org/10.1038/s41586-022-05554-8 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 14, 2022Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix. Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement. On a local level, the optimal stimulation site resided at the direct interface between these structures. Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes. Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming. Author(s) Source Ríos AS, Oxenford S, Neudorfer C et al. Nat Commun 13, 7707 (2022). https://doi.org/10.1038/s41467-022-34510-3 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 6, 2022When the makers of electronic implants abandon their projects, people who rely on the devices have everything to lose. Hundreds of thousands of people benefit from implanted neurotechnology every day. Among the most common devices are spinal-cord stimulators, first commercialized in 1968, that help to ease chronic pain. Cochlear implants that provide a sense of hearing, and deep-brain stimulation (DBS) systems that quell the debilitating tremor of Parkinson’s disease, are also established therapies. When the makers of implanted devices go under, the implants themselves are typically left in place — surgery to remove them is often too expensive or risky, or simply deemed unnecessary. But without ongoing technical support from the manufacturer, it is only a matter of time before the programming needs to be adjusted or a snagged wire or depleted battery renders the implant unusable. People are then left searching for another way to manage their condition, but with the added difficulty of a non-functional implant that can be an obstacle both to medical imaging and future implants. Author(s) Source Drew L nature, 6 Dec 2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 1, 2022Elon Musk and one of his other companies intend to begin testing computer chips in the brain next year. Neuralink will be able to insert the implant into a person’s brain in 06-2023, Musk announced at his startup’s annual press conference. The interface produced by Neuralink will make it possible to communicate directly with computers through thought, he said. So far, however, the prototypes, which are about the size of a coin, have only been implanted in animals. At the Neuralink presentation, monkeys were shown “playing” simple video games or moving a cursor on a screen with the help of the brain chip. Musk hopes to use the interfaces to cure neurological diseases. The startup is currently developing other implants to be inserted into the spinal cord or eyes to restore mobility or vision. However, Musk says his primary goal is to ensure that people are not intellectually overwhelmed by artificial intelligence systems. Author(s) Source afp/aerzteblatt.de aerzteblatt.de, 01.12.2022 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
November 19, 2022Oral diseases, while largely preventable, pose a major health burden for many countries and affect people throughout their lifetime, causing pain, discomfort, disfigurement and even death. It is estimated that oral diseases affect nearly 3.5 billion people. Untreated dental caries (tooth decay) in permanent teeth is the most common health condition according to the Global Burden of Disease 2019. Treatment for oral health conditions is expensive and usually not part of universal health coverage (UHC). Most low- and middle-income countries do not have sufficient services available to prevent and treat oral health conditions. Oral diseases are caused by a range of modifiable risk factors common to many noncommunicable diseases (NCDs), including sugar consumption, tobacco use, alcohol use and poor hygiene, and their underlying social and commercial determinants. Read more details at WHO (World Health Organization) Dental Implants may help if teeth are gone, but better they won´t get lost. Author(s) Source WHO 18.11.2022german comment This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
November 1, 2022From 2024, the Independent Patient Counseling Service (UPD) in Germany will no longer be run as a non-profit limited liability company but as a foundation under civil law. Ab 2024 wird die unabhängige Patientenberatung (UPD) in Deutschland nicht mehr als gemeinnützige GmbH sondern im Rahmen einer Stiftung bürgerlichen Rechts geführt. Despite funding by health insurers, the UPD is to operate independently. Also independently of the state and on an ongoing basis. It will be called “Stiftung Unabhängige Patientenberatung Deutschland (UPD)”. Information services are to be offered centrally and regionally. They should be low-threshold, citizen-oriented and barrier-free. A continuation or takeover of the structures of the previous UPD is not planned. Trotz der Finanzierung durch die Krankenversicherer soll die UPD unabhängig arbeiten. Sie soll staatsfern und kontinuierlich weiterge­führt werden. Sie wird „Stiftung Unabhängige Patientenberatung Deutschland (UPD)“ heißen. Informationsangebote sollen zentral und regional angeboten werden. Sie sollen niederschwellig, bürgernah und barrierefrei erreicht werden können. Eine Fortführung oder Übernahme der Strukturen der bisherigen UPD ist nicht vorgesehen. The fact that the planned legal form of a foundation is to be set up and financed by insurance companies – i.e. by the very organizations that very often trigger complaints and requests for advice from patients – is viewed critically. This would counteract the desired independence of the state. Kritisch wird gesehen, dass die geplante Rechtsform einer Stiftung durch Versicherungen eingerichtet und finanziert werden solle – also ausgerechnet von den Organisationen, die sehr häufig Auslöser von Beschwerden und Beratungsanliegen von Patienten seien. Damit würde die gewünschte Staatsferne konterkariert. Author(s) Source 1) bee/may/aerzteblatt.de 2) Andrick B 3) pr 1) aerzteblatt.de 20.10.20222) Vorschlag für einen Gesetzentwurf3) zm-online, 16.11.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 31, 2022In 2021 306,272 hip and knee replacements were recorded in the Endoprostheses Register Germany (EPRD). According to the report, the number of all documented knee interventions is eight percent below the comparable figures before the pandemic, while the number of hip interventions fell by just under one percent. Short stem and femoral neck prostheses together accounted for about 13 percent of fittings. However, at 32 hospitals, these stem types were used in more than half of the surgeries last year. The majority of hospitals chose full cementing for total knee arthroplasty in the vast majority of cases. 190 hospitals even implanted full-cement implants exclusively, and 81 other hospitals did so in more than 90 percent of cases. However, there were also 14 hospitals in which other types of anchorage predominated. According to the registry, the use of short stems is one of the trends in hip replacement care. They are now used in 12% of all hip implantations (6% the year before). There is a trend toward larger head components (36-mm heads were used in about 44 percent of cases, +3%). Author(s) Source © EB/aerzteblatt.de aerzteblatt.de, Endoprothesen­registerzeigt Versorgungs­unterschiede auf 31.10.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 29, 2022A computer screen shows the question “Would you like some water?” Underneath, three dots blink, followed by words that appear, one at a time: “No I am not thirsty.” It was brain activity that made those words materialize—the brain of a man who has not spoken for more than 15 years, ever since a stroke damaged the connection between his brain and the rest of his body, leaving him mostly paralyzed. We’re now pushing to expand to a broader vocabulary. To make that work, we need to continue to improve the current algorithms and interfaces, but I am confident those improvements will happen in the coming months and years. Now that the proof of principle has been established, the goal is optimization. We can focus on making our system faster, more accurate, and—most important— safer and more reliable. Things should move quickly now. Probably the biggest breakthroughs will come if we can get a better understanding of the brain systems we’re trying to decode, and how paralysis alters their activity. We’ve come to realize that the neural patterns of a paralyzed person who can’t send commands to the muscles of their vocal tract are very different from those of an epilepsy patient who can. We’re attempting an ambitious feat of BMI engineering while there is still lots to learn about the underlying neuroscience. We believe it will all come together to give our patients their voices back. Author(s) Source E Chang IEEE Spectrum, 29 Oct 2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 27, 2022Die Online-Plattform „Gesundheitsnavigator“ der deutschen Krankenversicherung AOK informiert jetzt darüber, welche Krankenhäuser bei kathetergestützten Aortenklappenimplantationen (transvaskulären Aortenklappenimplantationen, TAVI) besonders gute Behandlungsergebnisse vorweisen. Dafür können Ärzte und Patienten die Ergebnisse von 79 Kliniken abrufen, die in den Jahren 2018 bis 2020 eine solche TAVI bei knapp 23.000 Versicherten durchgeführt haben. Einer Analyse des Wissenschaftlichen Instituts der AOK (WidO) zufolge gab es im Viertel der Kliniken mit den besten Ergebnissen eine Gesamtkomplikationsrate von 5,1 Prozent. Im Viertel der Kliniken, die am schlechtes­ten abschneiden, liegt dieser Wert bei 7,1 Prozent. Die Auswertung zeigt zudem eine durchschnittliche Sterblichkeitsrate der behandelten Patienten von 2,8 Pro­zent. Im Viertel der Kliniken mit den besten Ergebnissen ist die Sterblichkeit nach TAVIs mit 2,1 Prozent nie­driger als im Viertel der schlechtesten Kliniken (3,8 Prozent). Auch bei der Häufigkeit von Herzinfarkten und Schlaganfällen innerhalb von 30 Tagen nach dem Eingriff gibt es Unterschiede: So erleiden im Viertel der Kliniken mit den besten Ergebnissen 1,8 Prozent der TAVI-Patien­ten innerhalb von 30 Tagen einen Schlaganfall, während es im schlechtesten Viertel 3,9 Prozent sind. Es lohne sich für einweisende Ärzte und betroffene Patienten, sich vorab über die Ergebnisse zur Behand­lungs­­qualität und über die Fallzahlen der Kliniken in ihrer Umgebung zu informieren, sagte die Vorstands­vorsitzende des AOK-Bundesverbandes, Carola Reimann. Author(s) Source anonymus aerzteblatt.de, 27 Oct 2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 17, 2022Endocarditis is an infectious disease of the inner lining of the heart (endocardium). It is frequently associated with severe progression (high morbidity) and often with a poor prognosis (high mortality). Therefore, antibiotics have been prescribed for prophylaxis in patients with a risk profile for endocarditis for more than 50 years. This antibiotic prophylaxis, which has been established for many years, aims to intercept bacteremia during invasive procedures in the oral cavity to reduce the risk of endocarditis. Single dose protocol: 30 – 60 minutes before the procedure: oral Amoxicillin not possible top take orally Ampicillin or Cefazolin or Ceftriaxone allergy to penicillin or ampicillin – oral Cefalexin or Azithromycin or Clarithromycin or Doxycyclin allergy to penicillin or ampicillin – no oral intake possible Cefazolin or Ceftriaxone Pay attention to exact dosage and instructions in the original article. According to the largely uniform recommendations of the American Heart Association in 2007 and the European Society of Cardiology in 2009, endocarditis prophylaxis should only be used in patients who belong to the following risk groups: survived endocarditis artificial heart valves patients with the following congenital heart defects: a) non-treated heart defects b) treated heart defects with residual defects c) heart defects repaired with artificial material after heart transplantation Author(s) Source Bilobrk P, Grötz KA ZZI 3/2022, DOI.org/10.53180/ ZZI.2022.0142–0144 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 12, 2022Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease. However, organoids lack the connectivity that exists in vivo, which limits maturation and makes integration with other circuits that control behaviour impossible. Here we show that human stem cell-derived cortical organoids transplanted into the somatosensory cortex of newborn athymic rats develop mature cell types that integrate into sensory and motivation-related circuits. MRI reveals post-transplantation organoid growth across multiple stem cell lines and animals, whereas single-nucleus profiling shows progression of corticogenesis and the emergence of activity-dependent transcriptional programs. Indeed, transplanted cortical neurons display more complex morphological, synaptic and intrinsic membrane properties than their in vitro counterparts, which enables the discovery of defects in neurons derived from individuals with Timothy syndrome. Anatomical and functional tracings show that transplanted organoids receive thalamocortical and corticocortical inputs, and in vivo recordings of neural activity demonstrate that these inputs can produce sensory responses in human cells. Finally, cortical organoids extend axons throughout the rat brain and their optogenetic activation can drive reward-seeking behaviour. Thus, transplanted human cortical neurons mature and engage host circuits that control behaviour. We anticipate that this approach will be useful for detecting circuit-level phenotypes in patient-derived cells that cannot otherwise be uncovered. Author(s) Source Revah O, Gore F, Kelley KW et al. Nature volume 610, 319–326 (2022) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 30, 2022The Zygoma implant was originally introduced by Brånemark in 1989 for the oral rehabilitation of patients who had undergone maxillectomy. It later evolved into an alternative treatment to avoid more extensive bone augmentations prior to masticatory rehabilitation of edentulous atrophic maxillae. This approach represents an adequate stabilization system in which the prosthetic provisional can provide additive implant stabilization immediately after surgery. However, given the anatomical characteristics of zygomatic processes and limited intraoperative visibility, surgical complications during zygoma implant placement – especially when multiple, adjacent zygoma implants are placed – often pose some challeng In the restoration of the atrophic maxilla, zygoma implants represent an option at least equivalent to two-stage restorations (augmentation and implant placement) with high survival rates and a low number of complications. Affected patients should also be informed about this option Author(s) Source Kämmerer PW, Fan S, Bjelopavlovic M, Kraus A, Sagheb K, Schiegnitz E ZZI 3/2022, DOI: 10.53180/ZZI.2022.0146–0150 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 13, 2022A research group from the Göttingen Cluster of Excellence Multiscale Bioimaging is working on an optogenetic cochlear implant (oCI). Electric cochlear implants (eCIs) are used by more than one million people worldwide and enable those affected to understand speech in a quiet environment. But those affected are known to have difficulty understanding speech in background noise, interpreting the emotional tone of speech, or enjoying melodies in music. Therefore, according to researchers, there is a great clinical need to improve hearing with CI. By combining an optical CI with gene therapy, they hope to achieve a fundamental improvement in frequency resolution. Gene therapy is used to introduce a light-activated ion channel into spiral ganglion neurons of the cochlea and make them light-sensitive. According to the team, what has already been successful in animal models now needs to be further developed for use in humans. The planned 64-channel optical CI should enable users to understand speech even in noisy environments, recognize speech melodies and enjoy melodies.Moser and his team have already provided preclinical proof of concept for gene therapy of the cochlea and for the optical CI as a new medical device. However, there is still a considerable need for research before the planned start of a first clinical trial in 2026, the group said. Author(s) Source hil/aerzteblatt.de dtsch aerzteblatt 13.09.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 9, 2022After a transient ischemic attack (TIA) or stroke, clinically stable patients do not appear to benefit from treatment with a stent. However, this may not be true for high-risk patients. This is shown by a Chinese-American study now published in the Journal of the American Medical Association (JAMA) (DOI: 10.1001/jama.2022.12000). The results of the new study confirm those of studies published eight years ago: In patients with intracranial stenoses who are in a clinically stable condition, stents provide no additional benefit. An indication for stent implantation is seen in patients with intracranial stenosis with a degree of stenosis of at least 70 percent who have suffered at least one further infarction after a stenosis-related infarction despite subsequent intensive drug therapy. “Not treating affected patients with progressive neurological symptoms at all because of a lack of data and waiting until a subsequent event occurs still seems questionable to us” (Diener). What is needed, on the other hand, is more precise patient selection so that those affected can receive therapy in a timely manner, the expert said. “A second event should be prevented and not waited for as an indication criterion” (P Berlit). Author(s) Source hil/aerzteblatt.de aerzteblatt.de 09.09.2022 (german) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 8, 2022The U.S. Food and Drug Administration (FDA) is informing the public about reports of cancers, including squamous cell carcinoma (SCC) and various lymphomas, in the scar tissue (capsule) that forms around breast implants. The various lymphomas reported are not the same as the lymphomas described in previous FDA Communications as Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). After preliminary review of published literature as part of our ongoing monitoring of the safety of breast implants, the FDA is aware of less than 20 cases of SCC and less than 30 cases of various lymphomas in the capsule around the breast implant. As of September 1, 2022, the FDA has received 10 medical device reports (MDRs) about SCC related to breast implants and 12 MDRs about various lymphomas related to breast implants. While the FDA believes that occurrences of SCC or various lymphomas in the capsule around the breast implant may be rare, health care providers and people who have or are considering breast implants should be aware that cases have been reported to the FDA and in the literature. Currently, the incidence rate and risk factors for SCC and various lymphomas in the capsule around the breast implants are unknown. This is an emerging issue and our understanding is evolving. For this reason, the FDA is asking health care providers and people with breast implants to report cases of SCC, lymphomas, or any other cancers around the breast implant to the FDA. Author(s) Source FDA FDA, 08.09.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
August 31, 2022Objective: To present and discuss a treatment concept with a minimally invasive procedure for the complete restoration of the maxilla and mandible. Material and method: The concept and clinical procedure for the use of extracted teeth for the fabrication of an autologous augmentation material is presented on the basis of a case study. It creates the basis for a comprehensive restoration based on the “all-on-six” procedure. The treatment includes immediate implant placement, digital impressions and intraoral bonding of the secondary and tertiary structures. The case study presented here shows how safe implant placement is possible even in cases that appear difficult (e.g. diabetes, periodontal predamage, alveolar ridge atrophy). The key to success lies in the consistent preference for less invasive procedures (e.g. flapless implant placement, autologous augmentation with autogenous dentin, omission of sinus lift by angulated positioning) and the use of established prosthetic protocols. Although the use of dentin grafts is currently not very widespread, the author believes that it has an underestimated potential. Author(s) Source Aleksandrov G Implantatgestützte Teleskopprothese. Z Zahnärztl Implantol 2022; 38: 152–156 (german original with pictures) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
August 29, 2022The complaint was filed by a 52-year-old woman, who had already undergone breast augmentation with saline implants at the age of 26. When she visited her gynecologist because of a leaking implant, he diagnosed breast cancer – both implants had to be removed. Two years after the operation, she applied for a new breast augmentation, according to the regional social court, citing psychological stress. She could not be expected to be satisfied with a situation that did not correspond to the aesthetics of the female body. The Regional Social Court now confirmed the opinion of the health insurance company: In the case of the plaintiff, there was neither an impairment of a bodily function nor a disfiguring anatomical deviation. A subjective burden due to the appearance could not justify an intervention, the court ruled – also because of the difficulties of predicting the psychological effects of physical changes. Author(s) Source dpa/aerzteblatt.de aerzteblatt de, 29.08.2022, State Social Court of Lower Saxony-Bremen, file no.: L 16 KR 344/21 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
August 22, 2022Background Randomized controlled trials (RCTs) that are highly restrictive in terms of study design, with highly selected participants and conditions, produce results whose applicability to routine clinical care and usefulness for reimbursement decisions is sometimes questioned. Objectives In view of the background mentioned above, do more pragmatic RCTs and registry-based RCTs offer potential solutions? What are the opportunities and risks associated with more pragmatic studies and which methodological aspects should be given special attention? Results Clinical RCTs for comparative effectiveness evaluation are located on a continuum from “very pragmatic” to “very explanatory”. No consented threshold exists from which an RCT is considered pragmatic. More pragmatic RCTs are often characterized by less selected but larger patient groups, embedding into a normal care setting, and patient-relevant outcomes. They usually dispense with longer-term assurance of patient adherence to the initially assigned treatment, blinding, and resource intensive intermediate examinations. However, this can lead to problems in interpretation, especially if no differences between interventions are shown. Conclusions More pragmatic RCTs and registry-based RCTs have the potential to become an important basis for decision-making in clinical practice, but also for health policy and reimbursement issues. However, in order to realize this potential, a number of hurdles – especially legal ones – have to be abolished. Author(s) Source Lange S, Lauterberg J Prävention und Gesundheitsförderung (2022) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
August 10, 2022Aim To present the 20-year clinical outcomes of tissue-level implants in partially edentulous patients previously treated for periodontitis and in periodontally healthy patients (PHP). Material and Methods The original population consisted of 149 partially edentulous patients consecutively enrolled in a private specialist practice and divided into three groups: PHP, moderately periodontally compromised patients (mPCP) and severely PCP (sPCP). After successful completion of periodontal/implant therapy, patients were enrolled in an individualized supportive periodontal care (SPC) programme. Results Eighty-four patients rehabilitated with 172 implants reached the 20-year examination. During the observation time, 12 implants were removed (i.e., 11 due to biological complications and 1 due to implant fracture), leading to an overall implant survival rate of 93% (i.e., 94.9% for PHP, 91.8% for mPCP and 93.1% for sPCP). At 20 years, PCP compliant with SPC did not present with significantly higher odds of implant loss compared with PHP compliant with SPC. Conversely, PCP not compliant with SPC experienced implant loss with odds ratio of 14.59. Conclusions Tissue-level implants, placed after comprehensive periodontal therapy and SPC, yield favourable long-term results. However, patients with a history of periodontitis and non-compliant with SPC are at higher risk of biological complications and implant loss. Author(s) Source A Roccuzzo, J-C Imber, C Marruganti, GE Salvi, G Ramieri, M Roccuzzo J of Clin Periodontology, 10 Aug 2022, https://doi.org/10.1111/jcpe.13716 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
July 25, 2022 Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement of memory impaired by injury or disease. Many pre-clinical DBS paradigms can be addressed in epilepsy patients undergoing intracranial monitoring for seizure localization, since they already have electrodes implanted in brain areas of interest. Even though epilepsy is usually not a memory disorder targeted by DBS, the studies can nevertheless model other memory-impacting disorders, such as Traumatic Brain Injury (TBI). These results show that hippocampal stimulation for memory facilitation was more beneficial for subjects who had previously suffered a brain injury (other than epilepsy), compared to control (epilepsy) subjects who had not suffered a brain injury. This study demonstrates that the epilepsy/intracranial recording model can be extended to test the ability of DBS to restore memory function in subjects who previously suffered a brain injury other than epilepsy, and support further investigation into the beneficial effect of DBS in TBI patients. Author(s) Source Roeder BM, Riley MR, She X et al. Front. Hum. Neurosci., 25 July 2022Sec. Brain Imaging and StimulationVol. 16 – 2022 https://doi.org/10.3389/fnhum.2022.933401 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
June 30, 2022Soft, bioresorbable coolers for reversible conduction block of peripheral nervesReeder et al. developed a soft, miniaturized, implantable cooler to temporarily block nerve conduction using a liquid-to-gas phase transition as the cooling mechanism (see the Perspective by Jiang and Hong). They borrowed the design of electrical nerve cuff and substituted electrical wires with a microfluidic channel carrying a microliter volume of bioinert coolant. A thermal thin-film sensor integrated within the cuff enabled monitoring of the temperature in real time, thus enabling closed-loop control. Implantable devices capable of targeted and reversible blocking of peripheral nerve activity may provide alternatives to opioids for treating pain. Local cooling represents an attractive means for on-demand elimination of pain signals, but traditional technologies are limited by rigid, bulky form factors; imprecise cooling; and requirements for extraction surgeries. Here, we introduce soft, bioresorbable, microfluidic devices that enable delivery of focused, minimally invasive cooling power at arbitrary depths in living tissues with real-time temperature feedback control. Construction with water-soluble, biocompatible materials leads to dissolution and bioresorption as a mechanism to eliminate unnecessary device load and risk to the patient without additional surgeries. Author(s) Source Reeder JT, Xie Z, Yang Q et al. SCIENCE, 30 Jun 2022, Vol 377, Issue 6601, pp. 109-115 DOI: 10.1126/science.abl8532 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
June 30, 2022Younger patients who receive an implantable defibrillator are significantly less likely than older defibrillator patients to suffer from CHD and extracardiac comorbidities. They also have a better ejection fraction, 42% versus 32%. However, they are twice as likely (16.4% versus 8.2%) to come in for revision because of device-associated complications than older patients S Hakmi, D-U Chun, Hamburg, Germany, DGK Annual Congress 2022, DEVICE Registry). The registry prospectively enrolled a total of 4181 patients from 50 centers in Germany between 2007 and 2011 who had received implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy with defibrillator (CRT-D). While heart failure was the most common reason for presentation in older patients, survived cardiac death, hypertrophic cardiomyopathies, and primary electrical heart disease dominated in younger patients. The 1-year mortality was lower in the young patients than in older patients, 3.1 versus 7.3%, respectively. Cardiologists attributed the higher complication rate to the greater activity of younger patients. Author(s) Source SuK Deutsches Ärzteblatt Dtsch Ärztebl 2022; 119(24): 4 (german) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
June 28, 2022A 57-year-old man with nonischemic cardiomyopathy who was dependent on venoarterial extracorporeal membrane oxygenation (ECMO) and was not a candidate for standard therapeutics, including a traditional allograft, received a heart from a genetically modified pig source animal that had 10 individual gene edits. Sudden diastolic thickening and failure of the xenograft occurred on day 49 after transplantation, and life support was withdrawn on day 60. On autopsy, the xenograft was found to be edematous, having nearly doubled in weight. Histologic examination revealed scattered myocyte necrosis, interstitial edema, and red-cell extravasation, without evidence of microvascular thrombosis — findings that were not consistent with typical rejection. Studies are under way to identify the mechanisms responsible for these changes. (Funded by the University of Maryland Medical Center and School of Medicine.) Author(s) Source Griffith BP, Goerlich CE, Singh AK, Rothblatt M et al. The New England Journal of Medicine, June 22, 2022, DOI: 10.1056/NEJMoa2201422 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
June 2, 2022tympanic membrane: Textile researchers at TU Dresden have developed a novel drumhead implant made of fibers. In tests conducted by the developers, the bioinspired innovation performed significantly better than conventional implants. The textile membrane enables a complete, permanent and lifelike reconstruction of the eardrum (D Aibibu). Tests have shown that the textile replacement eardrum has the same vibration characteristics as a real eardrum. Materials are polycaprolactone, a biodegradable plastic, and silk fibroin, a protein extracted from the cocoons of silkworms. Using an electrospinning process, which is also used to make stents for regenerative medicine, very fine threads are drawn from this protein-plastic solution and laid down to form a textile replacement eardrum. hip endoprosthesis: hip endoprosthesis can become loose and make revision require revision surgery. An endoprosthesis with a three-dimensional textile structure made of ceramic is being developed for this purpose. The material used also resembles hydroxyapatite. Author(s) Source Innomedia med engeneering 02.06.2022 (german) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...