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NEWS IN IMPLANTOLOGY

28 September 2016
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September 27, 2023Traditional prostheses after limb amputations allow only a part of the affected persons to achieve the desired and desired autonomous mobility. In analogy to dental implants, systems have been developed that allow the coupling of an exoprosthesis to a force carrier integrated in the bone and transmitted through the skin. Almost all of the problems associated with prosthetic limb replacement are due less to the functionality of the artificial joints and more to the prosthesis fixation systems that surround the residual limb. Therefore, starting in the 1990s, a concept analogous to dental implants was developed for limb replacement: A load bearing device permanently fixed in the bone and transmitted transcutaneously serves to couple the prosthesis.Such transcutaneous osseointegrated prosthesis systems (TOPS) represent a paradigm shift in care after limb amputation. They have become an indispensable part of the rehabilitation options, both in view of the high mobility gain and the significantly improved patient satisfaction. After initially proceeding in two stages and applying the stoma 4-6 weeks after insertion of the force carrier, the one-stage procedure has now proven successful. Depending on the bone quality of the soft tissue situation and the patient’s sensation, docking of the exoprosthesis by the orthopedic technician and subsequent mobilization can begin 3-6 weeks later. The interface between the endomodule and the exomodule is located between the conical sleeve and the knee connection adapter, which is firmly attached to the exoprosthesis and can be fixed or loosened by the patient with one hand. The knee joints are regularly equipped with microprocessors for control, as this minimizes the risk of falls. Between January 2003 and December 2021, the authors treated 244 patients (151 m/71 w) with a median age of 47.6 years (17-95 years), some bilaterally; long-term outcome data are available from 232 patients. To date, 13 femoral implants have been removed due to intramedullary infection, implant fatigue failure (after 7-14 years), chronic soft tissue problems, and patient request. TOPS reimplantation was successful in 4 of these patients. Author(s) Source Aschoff HH, Saß M, Mittlmeier Th, Fischer D-C Dtsch Arztebl 2023; 120(38): A-1518 / B-1304 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 22, 2023A 58-year-old patient with terminal heart disease became the second patient in the world to receive a successful transplant of a genetically-modified pig heart on September 20. He is recovering well and communicating with his loved ones. This new patient had end-stage heart disease. He was deemed ineligible for a traditional transplant with a human heart, by UMMC and several other leading transplant hospitals, due to his pre-existing peripheral vascular disease and complications with internal bleeding. This transplant was the only option available for this patient who was facing near-certain death from heart failure. Author(s) Source Deborah Kotz University of Maryland, Medical Center, Press release 22.09.2023 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 21, 2023Our society is aging. So the number of people who need an artificial hip joint, for example, is also rising. This can have long-term consequences for the healthcare system. “In more than ten percent of cases, loosening of the implanted prosthesis occurs within 15 years after hip surgery” (Alexander Franck, MD). The time of detection plays a decisive role in planning a new operation that may be necessary: the earlier loosening is detected, the lower the complications in the event of a prosthesis replacement. “The presence of mechanical loosening or loosening due to infection significantly influences treatment and prognosis.” Using measurement data, Jan Lützelberger’s team hopes to be able to make a statement about early loosening in the future using an ultrasound-based measurement method. In addition, the method offers, in principle, the possibility of detecting the formation of a bacterial film on the prosthesis. Author(s) Source Cindy Dötschel Coburg University, Press releas 21.09.2023 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 11, 2023The treatment of bone tumors or severe bone injuries often poses major problems for medicine. Titanium, for example, is used as a bone replacement material. There is a risk that the rigid implant will loosen, leading to long-term problems. A second therapeutic approach, he said, is to remove bone material from the pelvis, for example, and transplant it to the damaged area. However, this is then additionally associated with another defect. (Hermann Seitz, University of Rostock). It has been known for some time that barium titanate, a piezoelectric ceramic, can be used to generate voltage potentials under mechanical pressure. The barium titanate is combined with so-called bioactive glasses. This material is known to release ions when it comes into contact with body fluids, thus developing its bioactivity. This material is mixed with barium titanate and then put into the 3D printer. “We want to have an implant that responds piezoelectrically to mechanical stimuli and is bioactive at the same time.” The goal, he says, is to have bone cells migrate into the porous implant from the adjacent tissue. Once colonization and vascularization have occurred, the implant remains in the body. The implant can be made to fit precisely after digital reconstruction in a 3D printer. It will be many years before this technology clears the hurdle into everyday clinical use. Author(s) Source Nadine Rudolph Press release Rostock University, 11.09.2023 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
September 8, 2023A research group at the Department of Cardiothoracic, Transplantation and Vascular Surgery at the Hannover Medical School (MHH, Germany) is working on developing vascular prostheses based on the body’s own fibrin. Unlike conventional plastic models, the biologically active aortic prostheses are recognized by the immune system as the body’s own and are included in the body’s defense against infection. This should prevent the formation of biofilms. But the fibrin prostheses also have a major disadvantage: they cannot withstand the high pressure loads that prevail in the aortic bloodstream. This can be improved by spider silk. This is extremely thin and tear-resistant and completely degradable in the human body. Author(s) Source press release MHH hil/Dtsch Ärztebl 08.09.2023 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
August 14, 2023Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts. In this open-label, non-randomized phase I trial, we applied deep brain stimulation to the cerebellar dentate nucleus combined with renewed physical rehabilitation to promote functional reorganization of ipsilesional cortex in 12 individuals with persistent (1–3 years), moderate-to-severe upper-extremity impairment. No serious perioperative or stimulation-related adverse events were encountered, with participants demonstrating a seven-point median improvement on the Upper-Extremity Fugl-Meyer Assessment. All individuals who enrolled with partial preservation of distal motor function exceeded minimal clinically important difference regardless of time since stroke, with a median improvement of 15 Upper-Extremity Fugl-Meyer Assessment points. These robust functional gains were directly correlated with cortical reorganization evidenced by increased ipsilesional metabolism. Our findings support the safety and feasibility of deep brain stimulation to the cerebellar dentate nucleus as a promising tool for modulation of late-stage neuroplasticity for functional recovery and the need for larger clinical trials. Author(s) Source Baker KB, Plow EB, Nagel S et al. nature medicine, 14 Aug 2023 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
July 28, 2023Much has been developed in the field of prostheses and exoskeletons in recent years. However, the possibilities for a truly intuitive and, above all, non-invasive control systems are still lacking. The sensors currently in use are not sensitive enough for this. A consortium from research and industry wants to change that with the NeuroQ project. Last year, researchers at Fraunhofer IAF made a real breakthrough. For the first time, they were able to measure a magnetic field via stimulated emission. “So we have been able to show a magnetic field-dependent cavity signal, and for the first time.” The project leader, Jeske, is pleased to report. “Otherwise, we have only measured the magnetic field via fluorescence.” Compared to the fluorescence measurement, the laser signal was not only significantly stronger, but also much richer in contrast. Now the consortium must transfer this laser system, including the measurement methodology, into a sensor system and then integrate it into an industrially usable module Author(s) Source Anne Hofmann, Interview with Dr Jan Jeske, Deputy Business Unit Manager Quantum Devices, Fraunhofer Institute for Applied Solid State Physics IAF compamed tradefair, Düssseldorf 13-16 Nov 2023 exhibition This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
July 28, 2023Biomaterials required for 3D printing living cells are currently produced on an animal basis. A research project intends to develop materials based on human placental tissue for various 3D bioprinting technologies. 3D bioprinting aims to produce tissue structures for numerous applications such as non-animal testing, drug screening and regenerative medicine. The bio-materials used must be tailored to the needs of cells and keep them alive during and after the printing process. Author(s) Source HU3DINKS Consortium, Belgium and Austria Press release Up Nano, 28.07.2023 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
July 24, 2023Obesity prevalence has almost tripled worldwide since 1975 (Germany). Obesity is a risk factor for osteoarthritis of the hip and even more so of the knee. Compared to non-obese individuals, they have a higher risk of complications. The objective of this study was to analyze the association between obesity and complication rates, revision rates, and mortality after primary and revision hip and knee replacements. In our study, obesity was associated with an increased risk of revision surgery within one year. For hip arthroplasty, the risk of revision also increased with each BMI category. Recent studies have shown that obesity is associated with an increased rate of aseptic loosening resulting in prosthesis replacement. As well, an increased rate of infection has been reported in obese patients with subsequent removal or replacement of the prosthesis. Revision procedures for dislocation increased for hip implants with increasing BMI, whereas revisions decreased with increasing BMI. Obese patients continued to have higher rates of in-hospital adverse events in all groups, which was particularly evident in those with a BMI ≥ 40 kg/m². In-hospital mortality within 90 days was increased only in those with grade 3 obesity at primary procedures. Author(s) Source Jeschke E, Gehrke T, Günster C, et al. Dtsch Arztebl Int 2023; 120: 501-2; DOI: 10.3238/arztebl.m2023.0067 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
July 18, 2023A common European health data network is planned in the EU (European Health Data Space – EHDS). Problems are seen in the fact that the relationship of confidence and the doctor’s duty of secrecy must be maintained. The sovereignty of the data should remain with the patient. The EHDS is intended to manage secondary use of health data in addition to primary use. In this context, researchers, regulatory authorities, political decision-makers as well as industry (innovators, branch) are to be granted access to pseudonymized and anonymized data of EU citizens via a data access point for specific purposes. A board is to be established for monitoring purposes. Criticism is that the principles of data protection law, the principle of data minimization, data accuracy, storage limitation, integrity and confidentiality, and the principle of necessity are not sufficiently respected. Author(s) Source anonymous Hartmannbund Magazin 02/2023, 32-33 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
July 12, 2023According to the OECD, there are 204 hip replacements per 100,000 people in the USA, 315 in Germany, 128 in Spain and 68 in Israel. How long do patients in Germany and the United States stay in the hospital and rehab after hip replacement surgery? In Germany, about 10 nights in the hospital and twenty days in rehab are common. In America, patients are often out the day of surgery. They complete the rehabilitation afterwards at home under the guidance of skilled nursing staff. Patients in Germany were three times as frequent as those in the U.S. to require follow-up treatment within one month. Germans were almost twice as likely as Americans to need revision surgery within a year. Among those insured at Kaiser, those who were happiest with their new hip were those who had been in the hospital for a very short time. Was it due to pre-existing conditions? No. In terms of general health, the American patient cohort scored worse than the German cohort. Benedikt Simon, who knows both systems, blames the health care system for the big difference in the length of hospital stays. In Germany, hospitals bill insurers based on the number of cases. What happens before patients are admitted and after they are discharged doesn’t matter much. To prevent premature discharges, a minimum length of stay in the hospital is prescribed for hip joint operations. Otherwise, there are deductions. Kaiser insured patients pay a flat rate for their care, which the hospital then has to manage with. Author(s) Source Baltzer S Frankfurter Allgemeine Zeitung, 12.07.2023 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
May 22, 2023Chronic pain syndromes are often refractory to treatment and cause substantial suffering and disability. Pain severity is often measured through subjective report, while objective biomarkers that may guide diagnosis and treatment are lacking. Four individuals with refractory neuropathic pain were implanted with chronic intracranial electrodes in the anterior cingulate cortex and orbitofrontal cortex (OFC). We successfully predicted intraindividual chronic pain severity scores from neural activity with high sensitivity using machine learning methods. Author(s) Source Shirvalkar P, Prosky J, Chin G et al. nature neuroscience 22.05.2023 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
May 17, 2023The Implant Registry Germany has received the first data on breast implants from hospitals. This marks the start of trial operation, the Federal Ministry of Health (BMG) announced today. Technically, the register has been operational since March 31 of this year. The registry will deal with breast implants, as well as hip and knee endoprostheses. For breast implants, mandatory reporting is planned for January 1, 2024. Author(s) Source may/EB/aerzteblatt.de aerzteblatt.de 17.05.2023 (german text) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
April 17, 2023Battery electric vehicle (BEV) sales and use are rapidly expanding. Battery electric vehicles, along with their charging stations, are a potential source of electromagnetic interference (EMI) for patients with cardiac implantable electronic devices (CIEDs). The new ‘high-power’ charging stations have the potential to create strong electromagnetic fields and induce EMI in CIEDs, and their safety has not been evaluated. Conclusions The use of electric cars with high-power chargers by patients with cardiac devices appears to be safe with no evidence of clinically relevant EMI. Reasonable caution, by minimizing the time spent in close proximity with the charging cables, is still advised as the occurrence of very rare events cannot be excluded from our results. Author(s) Source Lennerz C, Schaarschmidt C, Blazek P et al. EP Europace, euad042, https://doi.org/10.1093/europace/euad042 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
March 28, 2023Treatment with Zygoma implants is a treatment option for edentulous patients in the maxilla to obtain a fixed prosthesis with implants within one day and even with very little jaw bone. Case report with pictures. Author(s) Source Kraus D Dentale Implantologie & Parodontologie 28.03.2023 (german) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
March 1, 2023Berlin – Health researchers are expecting progress from the EU Commission’s initiative for cross-border use of medical data. Health researcher Ferdinand Gerlach of the University of Frankfurt am Main highlighted the practical benefits of a European Health Data Space. It is a matter of life and health if physicians throughout Europe have access to medical data, including that of foreign patients, he said. The effective transfer of this information is important, for example, in the case of identified drug risks. Patients with rare diseases in particular benefit from the European Health Data Area, Gerlach added. This is because there are often not enough cases for research. The benefits of an EHDS are large and concrete, he said. Christof von Kalle of the Berlin Institute for Health Research at the Charité said it is about data spaces over which patients have power of disposal, but which must also be complete. In addition, the software products used must be designed to be interoperable. Manufacturers should be obliged to offer such transition points at no additional cost. Cryptography expert Dominique Schröder of the University of Erlangen-Nuremberg asserted that the processing of large amounts of data does not conflict with privacy and data protection. In the EU project, IT security should be involved from the beginning. Data protection law expert Fruzsina Molnar-Gabor of the Heidelberg Academy of Sciences also advocated the broad availability of health-related data. However, high data protection requirements would also have to be met. The EU is currently a long way from digital networking and interoperability, the data systems are too different and not linked nationally, she said. Marcel Weigand of the Independent Patient Counseling Service (UPD) spoke of a significant initiative in favor of patient care, according to the Bundestag. Already today, cross-border health services are available in several EU countries. Germany, on the other hand, is lagging behind and needs to catch up. Larger data volumes would also bring advantages in healthcare research. What is needed, however, are security, reliability and transparency. Author(s) Source © EB/aerzteblatt.de aerzteblatt.de 01.03.2023 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 28, 2023Fifty years after the term brain–computer interface was coined, the neurotechnology is being pursued by an array of start-up companies using a variety of different technologies. But the path to clinical and commercial success remains uncertain. Of the companies developing BCIs (brain-computer interface) with implanted recording systems, two are exclusively pursuing ECoG (electrocorticography) devices. The year 2023 promises to be significant for BCIs. Multiple non-invasive systems are likely to enter the hands of researchers and clinicians, and several key clinical trials of implanted systems are scheduled to begin. To succeed, BCIs must establish themselves as safe and truly helpful to people with serious medical conditions. Author(s) Source Drew L Nature Electronics volume 6, pages90–95 (2023) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 24, 2023Bioelectrodes have been developed to efficiently mediate electrical signals of biological systems as stimulators and recording devices. Recently, conductive hydrogels have garnered great attention as emerging materials for bioelectrode applications because they can permit intimate/conformal contact with living tissues and tissue-like softness. However, administration and control over the in vivo lifetime of bioelectrodes remain challenges. Here, injectable conductive hydrogels (ICHs) with tunable degradability as implantable bioelectrodes are developed. The hydrolyzable conductive hydrogels disappeared 3 days after in vivo administration, while the stable conductive hydrogels maintained their shapes for up to 7 days. Author(s) Source Park J, Lee S, Lee M, Kim H-S, Lee JY Wiley Online Library, nano micro small, 24.02.2023, https://doi.org/10.1002/smll.202300250 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 20, 2023Cerebral strokes can disrupt descending commands from motor cortical areas to the spinal cord, which can result in permanent motor deficits of the arm and hand. However, below the lesion, the spinal circuits that control movement remain intact and could be targeted by neurotechnologies to restore movement. Here we report results from two participants in a first-in-human study using electrical stimulation of cervical spinal circuits to facilitate arm and hand motor control in chronic post-stroke hemiparesis. We found that continuous stimulation through selected contacts improved strength, kinematics and functional movements, thereby enabling participants to perform movements that they could not perform without spinal cord stimulation. While we cannot conclusively evaluate safety and efficacy from two participants, our data provide promising, albeit preliminary, evidence that spinal cord stimulation could be an assistive as well as a restorative approach for upper-limb recovery after stroke. Author(s) Source Powell MP, Verma N, Sorensen E et al. Nat Med (2023). https://doi.org/10.1038/s41591-022-02202-6 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 17, 2023Hearing is a basic skill needed to participate in daily life. Hearing loss therefore often significantly limits the quality of life. Nevertheless, there are hardly any epidemiological data on the prevalence of hearing disorders in Germany. The study examined the prevalence of hearing impairment and the actual provision of hearing aids. In total, tonaudiometric data from 5 024 participants could be analyzed. The prevalence of hearing loss in at least one ear, regardless of severity, was 40.6% in the study population. Low-grade hearing loss was found in 22.5% of the participants, moderate hearing loss in 8.3%, and profound hearing loss in 2.8% (classification according to Röser from 1973). The hearing ability of women was better than that of men (on average by 4.3 dB). An increased prevalence of hearing impairment was seen with increasing age. Only 7.7% of participants had bilateral hearing aids. The discrepancy between the prevalence of hearing loss and the indication for hearing aid fitting results from the different ways in which hearing loss is determined and the indication is made. Conclusion: The prevalence of hearing loss was high at 40.6%. For the general population in Germany, regular hearing tests should be recommended from the age of 60 at the latest. Author(s) Source Döge J, Hackenberg B, O‘Brien K, Bohnert A, Rader T, Beutel ME, Münzel T, Pfeiffer N, Nagler M, Schmidtmann I, Wild PS, Matthias C, Bahr K Dtsch Arztebl Int 2023; 120: 99–106. DOI: 10.3238/arztebl.m2022.0385 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 17, 2023Key messages (zm): “Dental rehabilitation with dental implants in people with intermediate elevated blood glucose levels and diabetes mellitus is a safe and predictable procedure when properly indicated and a risk-based approach is used.” “In this context, diabetes mellitus should be classified as a potential risk indicator and this should be taken into account in patient management, treatment decisions as well as follow-up.” Author(s) Source DGZMK DGI et al. zm online 13.02.2023AWMF Leitlinie Registerno. 083-025 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 10, 2023Internet has become an increasingly important resource for health information, especially for lay people. However, the information found does not necessarily comply with the user’s health literacy level. Therefore, it is vital to identify prominent information providers, quantify the readability of written health information, and to analyze how different types of information sources are suited for people with differing health literacy levels. We were able to identify major information hubs as well as topics and themes within the sGHW. Results indicate that the readability within the sGHW is low. As a consequence, patients may face barriers, even though the vocabulary used seems appropriate from a medical perspective. In future work, the authors intend to extend their analyses to identify trustworthy health information web sites. Author(s) Source Zowalla R, Pfeifer D, Wetter T PLoS ONE 18(2): e0281582. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0281582 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 3, 2023Many patients wait years for a donor organ. This could soon change. “In a few years, if a woman develops breast cancer, we can reconstruct her breast with real cells,” says von Arnim of the Cellbricks company. The team has provided proof that the reproduction of cells using printing processes works in initial research projects. Together with scientists from the Berlin Institute of Health at the Charité, Cellbricks has printed a biological wound closure, for example. Author(s) Source Handelsblatt Handelsblatt disrupt 03.02.2023 (german) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
February 2, 2023The healthcare sector needs digitization, that is undisputed. The focus of the public debate so far has been on efficiency gains and cost savings, as well as data-driven improvements in care. The potential is enormous, because digitization creates resilience and strengthens Europe’s economic sovereignty, and – most importantly – it can cushion the industry’s biggest problem: Staff shortages. Digital innovations offer the only chance to defuse this problem, which has not yet reached the public’s awareness clearly enough. Because speed in digitization is no longer a desirable goal, but a bitter necessity. The focus will have to shift to innovations that increase efficiency and thus save resources. In particular, the automation of documentation can free up personnel to a considerable extent. So it is specifically about data-driven innovation. However, access to health data by academic players and the resulting scientific publications will hardly help. Only speed and short development cycles can help – and these can only be achieved through competition and industrial solutions. Legal certainty and clear guidelines for the use of data are essential prerequisites for innovation. At the moment, however, we are seeing exactly the opposite, with the EU Commission presenting new regulations at an unprecedented pace: The Data Governance Act, the Data Act, the AI Regulation, and the European Health Data Space Regulation (“EHDS-VO-E”). Many of these regulations are being discussed in parallel at the European and national levels. As a result, it is difficult for most companies in the industry to imagine in concrete terms what these regulations might mean in practice for their own business. The following aspects of the draft are particularly critical: 1. citizens are literally disenfranchised, and the right to informational self-determination is lost. The scope of the consent-free secondary use of data is tantamount to a complete loss of control by those affected. 2. If this data is nationalized, a kind of data socialism is created. This is because the regulation created an obligation for companies to provide all health data to so-called “access points.” The obligation to disclose all data collected in primary use destroys the motivation to gain an edge, for example, in publishing research results, through the cost-intensive collection of particularly good and structured data – this inevitably weakens Europe as a business location. 3. The greatest danger is that the dystopia of the “transparent citizen” will come true. Despite the ban, re-identification cannot be ruled out and the privacy of those affected is at risk, because data leaks basically provide everyone with the necessary profiles for re-identification – and large platform companies have access to quite a bit of personal data anyway. Initially anonymized and basically pseudonymized individual data records can often be reassigned to the original persons by linking them with other data records. The broad provision of anonymized and pseudonymized individual data records envisaged by the draft regulation is therefore problematic. The problem of anonymized data sets Anonymization of health data describes the process by which the personal parts of a data record, which are usually sensitive and worthy of protection, are removed or changed. This ensures that they can no longer be assigned to the specific person, or only with disproportionate effort. This forms the basis of the secondary use of health data and pursues the goal of protecting the privacy of patients and preventing misuse. Anonymization can be reversed by selectively linking different data sets – so-called re-identification. The problem is not limited to the healthcare industry. A specific case arose in 2007, for example, when Netflix published ten million movie rankings. Although these were anonymized and identifying data was replaced by random numbers, researchers managed to de-anonymize parts of the dataset by matching them with rankings and their timestamps from other movie websites – personal data was revealed. Preventing the creation of user profiles is difficult given the complexity of the systems and algorithms used. In addition, it is difficult to prove illegal use of data or violations of competition law. Legal measures introduced subsequently have been ineffective to date because the massive networking of different areas of life has created dependencies that make subsequent unbundling impracticable. (editorially abridged) Author(s) Source Vilsmeier S (CEO of Brainlab AG) FAZ 28.02.2023 (“Digitalisierung Europas: Wie die EU-Kommission Gesundheitsdaten verstaatlicht (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
January 31, 2023Studies have shown that magnetic resonance imaging (MRI) does not have clinically important effects on the device parameters of non–MRI-conditional implantable cardioverter-defibrillators (ICDs). However, data on non–MRI-conditional ICD detection and treatment of arrhythmias after MRI are limited. During a median follow-up of 2.2 years from MRI to latest available ICD interrogation before generator or lead exchange in 536 patients, 4177 arrhythmia episodes were detected, and 97 patients received ICD shocks. Sixty-one patients (10% of total) had 130 spontaneous ventricular tachycardia or fibrillation events terminated by ICD shocks. A total of 210 patients (33% of total) are known to have died (median, 1.7 years from MRI to death); 3 had cardiac arrhythmia deaths where shocks were indicated without direct evidence of device dysfunction. Conclusion: Non–MRI-conditional ICDs appropriately treated detected tachyarrhythmias after MRI. No serious adverse effects on device function were reported after MRI. Author(s) Source Ra J, Oberdier MT, Suzuki M et al. Annals of Internal Medicine, 31.Jan 2023, https://doi.org/10.7326/M22-2653 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
January 30, 2023Medical devices such as insulin pumps, defibrillators and brain stimulators are getting more and more connectivity. As more and more patients receive implants to treat conditions ranging from diabetes and Parkinson’s disease to deafness and heart failure, implants are becoming more complex – and thus more wirelessly controllable. This means that smartphones could soon be able to manage devices such as pacemakers and insulin pumps very easily and conveniently. The therapy method from the field of functional neurosurgery is called deep brain stimulation (DBS). It involves sending electrical impulses to the brain to relieve symptoms of Parkinson’s disease, chronic pain, depression, tremors or other medical disorders. Once these devices are connected to the Internet, they can give rise to threats known as “brainjacking.” If an attacker then succeeds in cracking a device’s previously inadequate security measures, he has several options for manipulating his victim’s implant. In this way, hackers are able to control a person’s behavior. Since neurostimulators currently cannot provide reliable security, a secure communication channel between the device programmer and the neurostimulator must be established. This can be achieved with a shared session key and symmetric encryption. Two major challenges need to be addressed: Generation of the session key. Secure transmission of the session key to the other party. It is also helpful to have a low transmission power, which can only be received when there is direct contact. Author(s) Source Geißler O Security Insider 30.01.2023 (german) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
January 24, 2023An ALS patient set a record for communicating via a brain implant: 62 words per minute. Eight years ago, a patient lost her power of speech because of ALS, or Lou Gehrig’s disease, which causes progressive paralysis. She can still make sounds, but her words have become unintelligible, leaving her reliant on a writing board or iPad to communicate. Now, after volunteering to receive a brain implant, the woman has been able to rapidly communicate phrases like “I don’t own my home” and “It’s just tough” at a rate approaching normal speech. Author(s) Source Regalado A MIT Technology Review, January 24, 2023 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
January 21, 2023Speech brain-computer interfaces (BCIs) have the potential to restore rapid communication to people with paralysis by decoding neural activity evoked by attempted speaking movements into text or sound.Early demonstrations, while promising, have not yet achieved accuracies high enough for communication of unconstrainted sentences from a large vocabulary. Here, we demonstrate the first speech-to-text BCI that records spiking activity from intracortical microelectrode arrays. Finally, we highlight two aspects of the neural code for speech that are encouraging for speech BCIs: spatially intermixed tuning to speech articulators that makes accurate decoding possible from only a small region of cortex, and a detailed articulatory representation of phonemes that persists years after paralysis. These results show a feasible path forward for using intracortical speech BCIs to restore rapid communication to people with paralysis who can no longer speak. Author(s) Source Willett F, Kunz E, Avansino D et al. bioRχiv Jan 21, 2023, doi: https://doi.org/10.1101/2023.01.21.524489 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
January 13, 2023Interim Safety Profile From the Feasibility Study of the BrainGate Neural Interface SystemBrain computer interfaces (BCIs) are being developed to restore mobility, communication, and functional independence to people with paralysis. Though supported by decades of preclinical data, the safety of chronically implanted microelectrode array BCIs in humans is unknown. We report safety results from the prospective, open-label, non-randomized BrainGate feasibility study (NCT00912041), the largest and longest-running clinical trial of an implanted BCI. Results: From 2004 – 2021, fourteen adults enrolled in the BrainGate trial had devices surgically implanted. The average duration of device implantation was 872 days, yielding 12,203 days of safety experience. There were 68 device-related adverse events, including 6 device-related serious adverse events. The most common device-related adverse event was skin irritation around the percutaneous pedestal. There were no safety events that required device explantation, no unanticipated adverse device events, no intracranial infections, and no participant deaths or adverse events resulting in permanently increased disability related to the investigational device. Discussion: The BrainGate Neural Interface system has a safety record comparable to other chronically implanted medical devices. Given rapid recent advances in this technology and continued performance gains, these data suggest a favorable risk/benefit ratio in appropriately selected individuals to support ongoing research and development. Author(s) Source Rubin DB, Ajiboye AB, Barefoot L et al. Neurology.org, January 13, 2023, DOI: https://doi.org/10.1212/WNL.0000000000201707 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
January 1, 2023Diabetics are known to frequently suffer from micro- and macroangiopathies. In addition, diabetes may be associated with increased wound healing disorders and compromised bone healing. Diabetes mellitus is therefore considered a relative risk factor for dental rehabilitation with implants, although dental implant surgery has emerged as a convenient oral rehabilitation tool in recent years. Against this background, the German Society of Implantology (DGI) and the German Society of Dental, Oral and Maxillofacial Medicine (DGZMK) have developed a current S3 guideline according to the guidelines of the Association of the Scientific Medical Societies (AWMF). Peri-implant infections after implant placement are particularly relevant in the presence of diabetes. Although the direct influence of diabetes mellitus on the development of peri-implant infections is not clear due to heterogeneous data, the risk of peri-implant infections seems to increase over time. The guideline recommends that patients with diabetes should be informed about the possibility of developing a peri-implant infection before starting therapy. The guideline provides recommendations for perioperative management in diabetics. For example, a disinfecting mouth rinse should be used perioperatively. In addition, the preoperative, prophylactic administration of a single antibiotic is recommended. There is no evidence in the literature that augmentation procedures have a higher complication and failure rate in patients with well-controlled diabetes mellitus compared to patients without diabetes mellitus. Patients with poorly controlled diabetes mellitus appear to have delayed osseointegration after implant placement; therefore, the indication for immediate and early loading should be particularly critical in these patients. The data on osseointegration in patients with well-controlled diabetes mellitus are very heterogeneous. However, after one year there seems to be no difference in implant stability between diabetics and healthy subjects. Overall, there are no significant differences in survival rates in the first years in patients with diabetes mellitus compared to the healthy comparison group. However, in the long-term course, the risk of implant loss still seems to be increased. Accordingly, a risk-oriented follow-up after implant placement should be performed. This also includes that the treating physician or dentist is informed about the patient’s HbA1c value and, if necessary, obtains further medical clarification. Author(s) Source editorial zm online 07/2023 (german original) german guideline 12-2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 31, 2022End-stage ankle osteoarthritis causes severe pain and disability. There are no randomized trials comparing the 2 main surgical treatments: total ankle replacement (TAR) and ankle fusion (AF). Between 6 March 2015 and 10 January 2019, a total of 303 patients were randomly assigned. At 52 weeks, the scores improved for both groups. The adjusted difference showed that TAR improved more than AF, but the difference was not considered clinically or statistically significant. The number of adverse events was similar between groups, but there were more wound healing issues in the TAR group and more thromboembolic events and nonunion in the AF group. The symptomatic nonunion rate for AF was 7%. A post hoc analysis suggested superiority of fixed-bearing TAR over AF. Author(s) Source Goldberg AJ, Chowdhury K, Bordea E et al. Annals of Internal Medicine, 12-2022, https://doi.org/10.7326/M22-2058 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 31, 2022The guideline addresses nonsurgical and surgical therapies for peri-implant mucositis and perimplantitis on dental implants. The main findings are: Complete healing of peri-implant mucositis could not be predictably achieved in all patients after using both alternative and conventional biofilm removal procedures. Therefore, regular follow-up visits (e.g., every 3 months) should be scheduled for early detection of the need for retreatment. Alternative biofilm removal procedures should be used for non-surgical treatment of peri-implantitis. If the treatment objective cannot be achieved by nonsurgical therapy, advanced lesions in particular should receive early surgical therapy. For further information, please refer to the original text (see below). The guideline is valid from December 2022 to December 2027 Author(s) Source DGI, DGZMK et al. AWMF 2022 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 31, 2022Die Leitlinie beschäftigt sich mit nichtchirurgischen und chirurgischen Therapien der periimplantären Mukositis und Perimplantitis an Zahnimplanaten. Die wichtigsten Empfehlungen sind: Eine vollständige Abheilung der periimplantären Mukositis konnte sowohl nach Einsatz alternativer als auch konventioneller Verfahren zur Biofilmentfernung nicht bei allen Patienten vorhersehbar erreicht werden. Daher sollten regelmäßige Nachkontrollen (z.B. alle 3 Monate) zur frühzeitigen Erkennung des Bedarfs einer Nachbehandlung eingeplant werden. Bei der nichtchirurgischen Therapie der Periimplantitis sollten alternative Verfahren zur Biofilmentfernung zum Einsatz kommen. Wenn das Behandlungsziel durch eine nichtchirurgische Therapie nicht erreicht werden kann, sollten insbesondere fortgeschrittene Läsionen frühzeitig einer chirurgischen Therapie zugeführt werden. Für weitere Informationen wird auf den Originaltext verwiesen (s.u.) Die Leitlinie gilt von Dezember 2022 bis Dezember 2027 Author(s) Source DGI, DGZMK et al. AWMF 2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 27, 2022Objective The restoration of extraction sockets as a pre-implantological measure in preparation for implant placement is of great importance for implant placement success. Unlike a surgical incision, which can be adapted and primarily closed, there is no soft tissue in the region of a former tooth. Therefore, wound healing after tooth extraction, i.e. alveolar closure physiologically undergoes secondary wound healing. In this context, the body must both regenerate the bony defect and close the soft tissue defect by means of newly formed soft tissue. In this context, contraction of the defect takes place. This process often brings complications, which can jeopardize the success of the implant.Platelet-Rich-Fibrin (PRF) Blood concentrates and in particular Platelet-Rich-Fibrin (PRF) offer a treatment option for the regeneration of lost tissue. PRF is derived from the patient’s own blood. Applications of PRF in Dental Implantology Its bioactivity as well as the potential of releasing a number of growth factors makes it a useful tool in augmentative and regenerative restoration of various defects. PRF is used both as a stand-alone therapy and in combination with bone graft substitutes or membranes. Both alveolar closure in terms of soft tissue and bone regeneration play an important role and thus influence the success of dental implants. Especially routine restorations of pre-implantological therapy such as socket/ridge preservation or sinus floor elevation are frequent fields of application. Recommendations and statements Filling the alveolus with solid PRF plug matrix leads to improvement of alveolar healing and can be recommended in case of open healing alveolus. The sole use of solid PRF plug matrix to fill the alveolus contributes to volume preservation of the alveolar ridge and can be recommended as an alternative treatment option if socket/ridge preservation is indicated.No treatment recommendation can be made at this time for the following procedures (PRF with or without bone graft substitutes): Sinus floor elevation. Lateral, vertical and three-dimensional augmentation. Immediate implant placement. Peri-implant disease. No treatment recommendation can be made for the sole use of solid PRF plug matrix to fill the alveolus to reduce pain sensation. Author(s) Source Deutsche Gesellschaft für Implantologie im Zahn-, Mund- und Kieferbereich (DGI) Deutsche Gesellschaft für Zahn-, Mund- und Kieferheilkunde (DGZMK) DGZMK.de, S3 Leitlinie 12-2022 (german language) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 22, 2022Cochlear implants are not only used in children born deaf, but increasingly also in adults with hearing loss. The implants take over the function of the cochlea and bypass the sensory cells. Thus, they directly stimulate the nerve cells of the auditory nerve. A speech processor breaks down sound into its frequencies and transmits the frequency, time and volume information to the stimulator. After the insertion of electrical cochlear implants, patients have to relearn how to hear because the small number of electrodes severely limits the perception of different pitches. This is not always easy and not all patients are happy with the implants in the end. As with the conventional electrical cochlear implant, the optical method breaks down sound into frequency bands, but now into many more and finer ones: 64 light guides assigned to the frequency bands transmit light into the inner ear. In this way, the implants provide a hearing impression even when no sensory cells are intact. Initial tests with computer simulations and rodents show that the technology works. For low and medium volumes, the differentiation of pitches is hardly distinguishable from normal hearing. The first study in humans is scheduled to begin in 2026. Author(s) Source Pietschmann C, Moser T Max-Planck-Gesellschaft 22.12.2022 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 21, 2022Study identifies neurons that can improve sound perception, which could explain the variation in performance in people with cochlear devices. Stimulating neurons that are linked to alertness helps rats with cochlear implants learn to quickly recognize tunes, researchers have found. The results suggest that activity in a brain region called the locus coeruleus (LC) improves hearing perception in deaf rodents. Researchers say the insights are important for understanding how the brain processes sound, but caution that the approach is a long way from helping people. Cochlear implants use electrodes in the inner-ear region called the cochlea, which is damaged in people who have severe or total hearing loss. The device converts acoustic sounds into electrical signals that stimulate the auditory nerve, and the brain learns to process these signals to make sense of the auditory world. Some people with cochlear implants learn to recognize speech within hours of the device being implanted, whereas others can take months or years. “This problem has been around since the dawn of cochlear implants, and it shows no signs of being resolved” (Gerald Loeb, USCLA). Researchers caution that stimulating the LC in humans could be dangerous. The region sends signals to many brain regions, and regulates the fight-or-flight response. Stimulating the LC in people “would raise blood pressure and heart rate, and other autonomic responses”, says Graeme Clark, an otolaryngologist in the Graeme Clark Institute at the University of Melbourne, Australia, who developed the first multi-channel cochlear implant in the 1970s. “We would have to do a series of experiments to prove that it is something worth doing.” Author(s) Source Naddaf M nature, 21 Dec 2022doi: https://doi.org/10.1038/d41586-022-04553-z This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 21, 2022Cochlear implants (CIs) are neuroprosthetic devices that can provide hearing to deaf people. Despite the benefits offered by CIs, the time taken for hearing to be restored and perceptual accuracy after long-term CI use remain highly variable. CI use is believed to require neuroplasticity in the central auditory system, and differential engagement of neuroplastic mechanisms might contribute to the variability in outcomes. Despite extensive studies on how CIs activate the auditory system, the understanding of CI-related neuroplasticity remains limited. One potent factor enabling plasticity is the neuromodulator noradrenaline from the brainstem locus coeruleus (LC). Here we examine behavioural responses and neural activity in LC and auditory cortex of deafened rats fitted with multi-channel CIs. Adequate engagement of central neuromodulatory systems is thus a potential clinically relevant target for optimizing neuroprosthetic device use. Author(s) Source Glennon E Valtcheva S, Zhu A, et al. Nature volume 613, pages317–323 (2023), https://doi.org/10.1038/s41586-022-05554-8 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 14, 2022Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix. Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement. On a local level, the optimal stimulation site resided at the direct interface between these structures. Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes. Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming. Author(s) Source Ríos AS, Oxenford S, Neudorfer C et al. Nat Commun 13, 7707 (2022). https://doi.org/10.1038/s41467-022-34510-3 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 9, 2022Inserting the implant into the inner ear is not without risks, as facial nerves can be injured in the process. Empa researchers have developed a new type of “smart” drill that minimizes this risk by automatically switching itself off when near nerves. Methods of “advanced manufacturing” could also lead to remarkable progress in other implantological fields. Here one can consider spinal surgery or dental implantology in the inferior mandibular nerve area. In combination with 3D planning and robotics, the procedure can be made not only safer but also much more minimally invasive. This also minimizes postoperative side effects. Author(s) Source EMPA Eidg. Materialprüfungs- und Forschungsanstalt BusinessLink 09.12.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 6, 2022When the makers of electronic implants abandon their projects, people who rely on the devices have everything to lose. Hundreds of thousands of people benefit from implanted neurotechnology every day. Among the most common devices are spinal-cord stimulators, first commercialized in 1968, that help to ease chronic pain. Cochlear implants that provide a sense of hearing, and deep-brain stimulation (DBS) systems that quell the debilitating tremor of Parkinson’s disease, are also established therapies. When the makers of implanted devices go under, the implants themselves are typically left in place — surgery to remove them is often too expensive or risky, or simply deemed unnecessary. But without ongoing technical support from the manufacturer, it is only a matter of time before the programming needs to be adjusted or a snagged wire or depleted battery renders the implant unusable. People are then left searching for another way to manage their condition, but with the added difficulty of a non-functional implant that can be an obstacle both to medical imaging and future implants. Author(s) Source Drew L nature, 6 Dec 2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 2, 2022The potentially available implantation time options each present different clinical difficulties and treatment risks. The selection of the implantation time slot is determined by the individual patient’s systemic and local factors. The selected implantation timing may have a negative impact on survival and success. Late implantation (Implantation after 4-6 months at the soonest): High implant survival rates. For late implant placement, it is significant that resorption processes occur in the area of the alveolus after tooth extraction, which can lead to vertical and horizontal bone loss on a patient-specific basis. If a late implant placement is indicated for patient-specific reasons, an alveolar ridge preservation (ARP) procedure should be recommended after tooth extraction. Soon implantation Early implantation can be recommended, if, due to acute inflammatory processes or anatomical compromise immediate implant placement may not be indicated. The aim of early implant placement is to shorten the treatment time of late implant placement and to bypass at the same time disadvantages of immediate implant placement. One of the most important advantages is the completed soft tissue healing. Early implantations showed a very good implant survival rate of 91-100%. However, comparative prospective studies at other implantation time points are only available in very limited numbers. A recent systematic review showed no significant difference in implant survival depending on the time of implantation. Long-term stable peri-implant conditions can be achieved by augmentative measures during early implantation. Immediate implantation showed a reduced survival rate compared to soon or late implantation. Immediate implant placement is a complex surgical procedure and requires appropriate clinical expertise. Since its success depends on a variety of patient-sided systemic and local factors, the indication for each case should be made individually after careful consideration. More Patients under medication with bone antiresorptive drugs or with radiatio in the head and neck region show a reduced rate of bone remodeling and bone new bone formation rate. Therefore, the indication for immediate implant placement and soon implantation should not be made. Regardless of the time of implant placement, the untreated periodontally infected residual dentition is a risk to the success of the implant and should therefore be addressed prior to implant placement. Taking a three-dimensional radiograph provides accurate bone dimension and possible local pathologies information and can be helpful for the decision-making process for immediate implant placement. In patients with a thick gingival type, thick and intact vestibular bone lamella (> 1mm) and a small horizontal gap between the implant and the vestibular bone lamella (<2mm), simultaneous augmentation during immediate implant placement can be omitted. In case of thin gingival type or thin vestibular bone lamella and vertical tissue deficit in the esthetic zone, simultaneous soft tissue and/or hard tissue augmentation/optimization should be performed during immediate implant placement. Immediate implant placement can be performed with careful consideration of the indications in a chronically infected alveola without acute clinical symptoms. Summary Treatment planning for implant therapy should begin as soon as the indication for a tooth extraction with subsequent implantological treatment. The possible implantation schedules are differentiated with different clinical difficulties and treatment risks. The selection of the time of implantation is determined by the individual patient’s systemic and local factors. With regard to the systemic risk factors, it should be noted that a variety of diseases or therapies result in a compromised bone remodeling and new bone formation rate. This disturbed bone physiology should be taken into account by the clinician when determining the time of implantation. The timing of the implantation may have a negative impact on the survival and success if the specific requirements are not or only partially fulfilled. Furthermore, the decision is influenced by a multitude of local factors and is directly dependent on the respective soft and hard tissue properties of the alveola in the process of healing. and hard tissue properties of the healing alveolus.The predictability of implant success is largely determined by these local factors, although the initial local situation can be modified by augmentative measures. Implant placement is a technique-sensitive surgical intervention that varies in complexity depending on the time of implant placement, thus requires different prerequisites on the clinical expertise of the practitioner. Finally, the advantages and disadvantages of the various implant placement protocols must be analyzed on a patient-specific basis and carefully weighed for each case. Author(s) Source Walter CH, Sagheb K et al. S2k-guideline, AWMF-Reg.-No. 083-040 Germany, DGZMK DGI (German original), 02.12.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
December 1, 2022Elon Musk and one of his other companies intend to begin testing computer chips in the brain next year. Neuralink will be able to insert the implant into a person’s brain in 06-2023, Musk announced at his startup’s annual press conference. The interface produced by Neuralink will make it possible to communicate directly with computers through thought, he said. So far, however, the prototypes, which are about the size of a coin, have only been implanted in animals. At the Neuralink presentation, monkeys were shown “playing” simple video games or moving a cursor on a screen with the help of the brain chip. Musk hopes to use the interfaces to cure neurological diseases. The startup is currently developing other implants to be inserted into the spinal cord or eyes to restore mobility or vision. However, Musk says his primary goal is to ensure that people are not intellectually overwhelmed by artificial intelligence systems. Author(s) Source afp/aerzteblatt.de aerzteblatt.de, 01.12.2022 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
November 19, 2022Oral diseases, while largely preventable, pose a major health burden for many countries and affect people throughout their lifetime, causing pain, discomfort, disfigurement and even death. It is estimated that oral diseases affect nearly 3.5 billion people. Untreated dental caries (tooth decay) in permanent teeth is the most common health condition according to the Global Burden of Disease 2019. Treatment for oral health conditions is expensive and usually not part of universal health coverage (UHC). Most low- and middle-income countries do not have sufficient services available to prevent and treat oral health conditions. Oral diseases are caused by a range of modifiable risk factors common to many noncommunicable diseases (NCDs), including sugar consumption, tobacco use, alcohol use and poor hygiene, and their underlying social and commercial determinants. Read more details at WHO (World Health Organization) Dental Implants may help if teeth are gone, but better they won´t get lost. Author(s) Source WHO 18.11.2022german comment This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
November 1, 2022From 2024, the Independent Patient Counseling Service (UPD) in Germany will no longer be run as a non-profit limited liability company but as a foundation under civil law. Ab 2024 wird die unabhängige Patientenberatung (UPD) in Deutschland nicht mehr als gemeinnützige GmbH sondern im Rahmen einer Stiftung bürgerlichen Rechts geführt. Despite funding by health insurers, the UPD is to operate independently. Also independently of the state and on an ongoing basis. It will be called “Stiftung Unabhängige Patientenberatung Deutschland (UPD)”. Information services are to be offered centrally and regionally. They should be low-threshold, citizen-oriented and barrier-free. A continuation or takeover of the structures of the previous UPD is not planned. Trotz der Finanzierung durch die Krankenversicherer soll die UPD unabhängig arbeiten. Sie soll staatsfern und kontinuierlich weiterge­führt werden. Sie wird „Stiftung Unabhängige Patientenberatung Deutschland (UPD)“ heißen. Informationsangebote sollen zentral und regional angeboten werden. Sie sollen niederschwellig, bürgernah und barrierefrei erreicht werden können. Eine Fortführung oder Übernahme der Strukturen der bisherigen UPD ist nicht vorgesehen. The fact that the planned legal form of a foundation is to be set up and financed by insurance companies – i.e. by the very organizations that very often trigger complaints and requests for advice from patients – is viewed critically. This would counteract the desired independence of the state. Kritisch wird gesehen, dass die geplante Rechtsform einer Stiftung durch Versicherungen eingerichtet und finanziert werden solle – also ausgerechnet von den Organisationen, die sehr häufig Auslöser von Beschwerden und Beratungsanliegen von Patienten seien. Damit würde die gewünschte Staatsferne konterkariert. Author(s) Source 1) bee/may/aerzteblatt.de 2) Andrick B 3) pr 1) aerzteblatt.de 20.10.20222) Vorschlag für einen Gesetzentwurf3) zm-online, 16.11.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 31, 2022In 2021 306,272 hip and knee replacements were recorded in the Endoprostheses Register Germany (EPRD). According to the report, the number of all documented knee interventions is eight percent below the comparable figures before the pandemic, while the number of hip interventions fell by just under one percent. Short stem and femoral neck prostheses together accounted for about 13 percent of fittings. However, at 32 hospitals, these stem types were used in more than half of the surgeries last year. The majority of hospitals chose full cementing for total knee arthroplasty in the vast majority of cases. 190 hospitals even implanted full-cement implants exclusively, and 81 other hospitals did so in more than 90 percent of cases. However, there were also 14 hospitals in which other types of anchorage predominated. According to the registry, the use of short stems is one of the trends in hip replacement care. They are now used in 12% of all hip implantations (6% the year before). There is a trend toward larger head components (36-mm heads were used in about 44 percent of cases, +3%). Author(s) Source © EB/aerzteblatt.de aerzteblatt.de, Endoprothesen­registerzeigt Versorgungs­unterschiede auf 31.10.2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 29, 2022A computer screen shows the question “Would you like some water?” Underneath, three dots blink, followed by words that appear, one at a time: “No I am not thirsty.” It was brain activity that made those words materialize—the brain of a man who has not spoken for more than 15 years, ever since a stroke damaged the connection between his brain and the rest of his body, leaving him mostly paralyzed. We’re now pushing to expand to a broader vocabulary. To make that work, we need to continue to improve the current algorithms and interfaces, but I am confident those improvements will happen in the coming months and years. Now that the proof of principle has been established, the goal is optimization. We can focus on making our system faster, more accurate, and—most important— safer and more reliable. Things should move quickly now. Probably the biggest breakthroughs will come if we can get a better understanding of the brain systems we’re trying to decode, and how paralysis alters their activity. We’ve come to realize that the neural patterns of a paralyzed person who can’t send commands to the muscles of their vocal tract are very different from those of an epilepsy patient who can. We’re attempting an ambitious feat of BMI engineering while there is still lots to learn about the underlying neuroscience. We believe it will all come together to give our patients their voices back. Author(s) Source E Chang IEEE Spectrum, 29 Oct 2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 27, 2022Die Online-Plattform „Gesundheitsnavigator“ der deutschen Krankenversicherung AOK informiert jetzt darüber, welche Krankenhäuser bei kathetergestützten Aortenklappenimplantationen (transvaskulären Aortenklappenimplantationen, TAVI) besonders gute Behandlungsergebnisse vorweisen. Dafür können Ärzte und Patienten die Ergebnisse von 79 Kliniken abrufen, die in den Jahren 2018 bis 2020 eine solche TAVI bei knapp 23.000 Versicherten durchgeführt haben. Einer Analyse des Wissenschaftlichen Instituts der AOK (WidO) zufolge gab es im Viertel der Kliniken mit den besten Ergebnissen eine Gesamtkomplikationsrate von 5,1 Prozent. Im Viertel der Kliniken, die am schlechtes­ten abschneiden, liegt dieser Wert bei 7,1 Prozent. Die Auswertung zeigt zudem eine durchschnittliche Sterblichkeitsrate der behandelten Patienten von 2,8 Pro­zent. Im Viertel der Kliniken mit den besten Ergebnissen ist die Sterblichkeit nach TAVIs mit 2,1 Prozent nie­driger als im Viertel der schlechtesten Kliniken (3,8 Prozent). Auch bei der Häufigkeit von Herzinfarkten und Schlaganfällen innerhalb von 30 Tagen nach dem Eingriff gibt es Unterschiede: So erleiden im Viertel der Kliniken mit den besten Ergebnissen 1,8 Prozent der TAVI-Patien­ten innerhalb von 30 Tagen einen Schlaganfall, während es im schlechtesten Viertel 3,9 Prozent sind. Es lohne sich für einweisende Ärzte und betroffene Patienten, sich vorab über die Ergebnisse zur Behand­lungs­­qualität und über die Fallzahlen der Kliniken in ihrer Umgebung zu informieren, sagte die Vorstands­vorsitzende des AOK-Bundesverbandes, Carola Reimann. Author(s) Source anonymus aerzteblatt.de, 27 Oct 2022 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 17, 2022Endocarditis is an infectious disease of the inner lining of the heart (endocardium). It is frequently associated with severe progression (high morbidity) and often with a poor prognosis (high mortality). Therefore, antibiotics have been prescribed for prophylaxis in patients with a risk profile for endocarditis for more than 50 years. This antibiotic prophylaxis, which has been established for many years, aims to intercept bacteremia during invasive procedures in the oral cavity to reduce the risk of endocarditis. Single dose protocol: 30 – 60 minutes before the procedure: oral Amoxicillin not possible top take orally Ampicillin or Cefazolin or Ceftriaxone allergy to penicillin or ampicillin – oral Cefalexin or Azithromycin or Clarithromycin or Doxycyclin allergy to penicillin or ampicillin – no oral intake possible Cefazolin or Ceftriaxone Pay attention to exact dosage and instructions in the original article. According to the largely uniform recommendations of the American Heart Association in 2007 and the European Society of Cardiology in 2009, endocarditis prophylaxis should only be used in patients who belong to the following risk groups: survived endocarditis artificial heart valves patients with the following congenital heart defects: a) non-treated heart defects b) treated heart defects with residual defects c) heart defects repaired with artificial material after heart transplantation Author(s) Source Bilobrk P, Grötz KA ZZI 3/2022, DOI.org/10.53180/ ZZI.2022.0142–0144 (german original) This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 13, 2022Whether revascularization by percutaneous coronary intervention (PCI) can improve event-free survival and left ventricular function in patients with severe ischemic left ventricular systolic dysfunction, as compared with optimal medical therapy (i.e., individually adjusted pharmacologic and device therapy for heart failure) alone, is unknown. CONCLUSIONS Among patients with severe ischemic left ventricular systolic dysfunction who received optimal medical therapy, revascularization by PCI did not result in a lower incidence of death from any cause or hospitalization for heart failure. Author(s) Source Perera D, Clayton T, O´Kane P et al. N Engl J Med 2022; 387:1351-1360DOI: 10.1056/NEJMoa2206606 This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...
October 12, 2022Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease. However, organoids lack the connectivity that exists in vivo, which limits maturation and makes integration with other circuits that control behaviour impossible. Here we show that human stem cell-derived cortical organoids transplanted into the somatosensory cortex of newborn athymic rats develop mature cell types that integrate into sensory and motivation-related circuits. Transplanted human cortical neurons mature and engage host circuits that control behaviour. We anticipate that this approach will be useful for detecting circuit-level phenotypes in patient-derived cells that cannot otherwise be uncovered. Author(s) Source Revah O, Gore F, Kelley KW et al. Nature 610, 319–326 (2022). https://doi.org/10.1038/s41586-022-05277-w This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register. Comments: n/alet us know [...] Read more...

 

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