Use of Platelet-Rich-Fibrin (PRF) in Dental Implantology (guideline, GERMANY)

The restoration of extraction sockets as a pre-implantological measure in preparation for implant placement is of great importance for implant placement success. Unlike a surgical incision, which can be adapted and primarily closed, there is no soft tissue in the region of a former tooth. Therefore, wound healing after tooth extraction, i.e. alveolar closure physiologically undergoes secondary wound healing. In this context, the body must both regenerate the bony defect and close the soft tissue defect by means of newly formed soft tissue. In this context, contraction of the defect takes place. This process often brings complications, which can jeopardize the success of the implant.Platelet-Rich-Fibrin (PRF)
Blood concentrates and in particular Platelet-Rich-Fibrin (PRF) offer a treatment option for the regeneration of lost tissue. PRF is derived from the patient’s own blood.

Applications of PRF in Dental Implantology
Its bioactivity as well as the potential of releasing a number of growth factors makes it a useful tool in augmentative and regenerative restoration of various defects. PRF is used both as a stand-alone therapy and in combination with bone graft substitutes or membranes. Both alveolar closure in terms of soft tissue and bone regeneration play an important role and thus influence the success of dental implants. Especially routine restorations of pre-implantological therapy such as socket/ridge preservation or sinus floor elevation are frequent fields of application.

Recommendations and statements
Filling the alveolus with solid PRF plug matrix leads to improvement of alveolar healing and can be recommended in case of open healing alveolus.
The sole use of solid PRF plug matrix to fill the alveolus contributes to volume preservation of the alveolar ridge and can be recommended as an alternative treatment option if socket/ridge preservation is indicated.No treatment recommendation can be made at this time for the following procedures (PRF with or without bone graft substitutes):

No treatment recommendation can be made for the sole use of solid PRF plug matrix to fill the alveolus to reduce pain sensation.

Author(s) Source
Deutsche Gesellschaft für Implantologie im Zahn-, Mund- und Kieferbereich (DGI) Deutsche Gesellschaft für Zahn-, Mund- und Kieferheilkunde (DGZMK), S3 Leitlinie 12-2022 (german language)
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