NEWS on cardiovascular, respiratory system implants
Implantable Defibrillator System Shock Function, Mortality, and Cause of Death After Magnetic Resonance Imaging
Studies have shown that magnetic resonance imaging (MRI) does not have clinically important effects on the device parameters of non–MRI-conditional implantable cardioverter-defibrillators (ICDs). However, data on non–MRI-conditional ICD detection and treatment of arrhythmias after MRI are limited. During a median follow-up of 2.2 years from MRI to latest available ICD...
Deutsche AOK informiert über Qualitätsergebnisse bei kathetergestütztem Aortenklappenersatz
Die Online-Plattform „Gesundheitsnavigator“ der deutschen Krankenversicherung AOK informiert jetzt darüber, welche Krankenhäuser bei kathetergestützten Aortenklappenimplantationen (transvaskulären Aortenklappenimplantationen, TAVI) besonders gute Behandlungsergebnisse vorweisen. Dafür können Ärzte und Patienten die Ergebnisse von 79 Kliniken abrufen, die in den Jahren 2018 bis 2020 eine solche TAVI bei knapp 23.000 Versicherten durchgeführt haben. Einer...
Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction
Whether revascularization by percutaneous coronary intervention (PCI) can improve event-free survival and left ventricular function in patients with severe ischemic left ventricular systolic dysfunction, as compared with optimal medical therapy (i.e., individually adjusted pharmacologic and device therapy for heart failure) alone, is unknown. CONCLUSIONS Among patients with severe ischemic left...
TIA (transient ischemic attack) and stroke: neurologists for more precise patient selection for stent treatments
After a transient ischemic attack (TIA) or stroke, clinically stable patients do not appear to benefit from treatment with a stent. However, this may not be true for high-risk patients. This is shown by a Chinese-American study now published in the Journal of the American Medical Association (JAMA) (DOI: 10.1001/jama.2022.12000)....
Efficacy and Safety of an Extravascular, substernally implanted Cardioverter–Defibrillator
The extravascular implantable cardioverter–defibrillator (ICD) has a single lead implanted substernally to enable pause-prevention pacing, antitachycardia pacing, and defibrillation energy similar to that of transvenous ICDs. The safety and efficacy of extravascular ICDs are not yet known. In this prospective global study, we found that extravascular ICDs were implanted safely...
Younger patients experiencing more complications with cardioverter defibrillators
Younger patients who receive an implantable defibrillator are significantly less likely than older defibrillator patients to suffer from CHD and extracardiac comorbidities. They also have a better ejection fraction, 42% versus 32%. However, they are twice as likely (16.4% versus 8.2%) to come in for revision because of device-associated complications...
Genetically Modified Porcine-to-Human Cardiac Xenotransplantation
A 57-year-old man with nonischemic cardiomyopathy who was dependent on venoarterial extracorporeal membrane oxygenation (ECMO) and was not a candidate for standard therapeutics, including a traditional allograft, received a heart from a genetically modified pig source animal that had 10 individual gene edits. Sudden diastolic thickening and failure of the...
Supplemental calcium and vitamin D and long-term mortality in aortic stenosis
Calcium metabolism has long been implicated in aortic stenosis (AS). Studies assessing the long-term safety of oral calcium and/or vitamin D in AS are scarce yet imperative given the rising use among an elderly population prone to deficiency. We sought to identify the associations between supplemental calcium and vitamin D...
Spatially Heterogeneous Tubular Scaffolds for In Situ Heart Valve Tissue Engineering Using Melt Electrowriting
Heart valve tissue engineering (HVTE) aims to provide living autologous heart valve implants endowed with regenerative capabilities and life-long durability. However, fabrication of biomimetic scaffolds capable of providing the required functionality in terms of mechanical performance and tunable porosity to enable cellular infiltration remains a major challenge. Here, the additive...
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