Development of rupture-resistant bioprostheses for aortic aneurysms

A research group at the Department of Cardiothoracic, Transplantation and Vascular Surgery at the Hannover Medical School (MHH, Germany) is working on developing vascular prostheses based on the body’s own fibrin.
Unlike conventional plastic models, the biologically active aortic prostheses are recognized by the immune system as the body’s own and are included in the body’s defense against infection. This should prevent the formation of biofilms.
But the fibrin prostheses also have a major disadvantage: they cannot withstand the high pressure loads that prevail in the aortic bloodstream. This can be improved by spider silk. This is extremely thin and tear-resistant and completely degradable in the human body.
Author(s) Source
press release MHH hil/Dtsch Ärztebl 08.09.2023
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