NEWS-Cardiovascular, Respiratory System

A growth-accommodating implant for paediatric applications

Medical implants of fixed size cannot accommodate normal tissue growth in children and often require eventual replacement or—in some cases—removal, leading to repeated interventions, increased complication rates and worse outcomes.  Feins EN et al. Implants that can correct anatomical deformities and accommodate tissue growth remain an unmet need. Here, we report the design and use …

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Bioresorbable Scaffolds versus Metallic Stents in Routine PCI

In this preliminary report of a trial involving patients undergoing PCI, there was no significant difference in the rate of target-vessel failure between the patients who received a bioresorbable scaffold and the patients who received a metallic stent. The bioresorbable scaffold was associated with a higher incidence of device thrombosis than the metallic stent through …

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Cardiopatch for heart tissue

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues IY Shadrin et al. Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues for human therapy are lacking. Here we present a “Cardiopatch” platform for …

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Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure

Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure Lars Køber et al. In this trial, prophylactic ICD implantation in patients with symptomatic systolic heart failure not caused by coronary artery disease was not associated with a significantly lower long-term rate of death from any cause than was usual clinical care. August 28, 2016, DOI: …

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Drug-coated balloons for small coronary artery disease

Drug-coated balloons for small coronary artery disease (BASKET-SMALL 2): an open-label randomised non-inferiority trial Jeger RV, et al. In small native coronary artery disease, DCB was non-inferior to DES regarding MACE up to 12 months, with similar event rates for both treatment groups. The Lancet, Articles| Volume 392, ISSUE 10150, P849-856, September 08, 2018, https://doi.org/10.1016/S0140-6736(18)31719-7 This …

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Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease

Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease Bonaa KH et al In patients undergoing PCI, there were no significant differences between those receiving drug-eluting stents and those receiving bare-metal stents in the composite outcome of death from any cause and nonfatal spontaneous myocardial infarction. Rates of repeat revascularization were lower in the group receiving …

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Drug-eluting stents (DES) superior versus bare-metal stents

In the ISAR-CABG (Is Drug-Eluting-Stenting Associated with Improved Results in Coronary Artery Bypass Grafts?) trial, clinical outcomes at 1 year in patients undergoing treatment of saphenous vein graft lesions were superior with drug-eluting stents (DES) versus bare-metal stents. R Colleran et al. Patients were randomized (1:1:1:3) to receive DES (either permanent-polymer paclitaxel-eluting stents, permanent-polymer sirolimus-eluting …

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ESC/EACTS Guidelines for the management of valvular heart disease 2017

2017 ESC/EACTS Guidelines for the management of valvular heart disease European Heart Journal, Volume 38, Issue 36, 21 September 2017, Pages 2739–2791 The Task Force for the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) The disclosure forms of all experts involved in …

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Foramen Ovale Closure after Stroke

Among adults who had had a cryptogenic ischemic stroke, closure of a PFO was associated with a lower rate of recurrent ischemic strokes than medical therapy alone during extended follow-up. (Funded by St. Jude Medical; RESPECT ClinicalTrials.gov number, NCT00465270.) Supported by St. Jude Medical. N Engl J Med 2017; 377:1022-1032September 14, 2017DOI: 10.1056/NEJMoa1610057 Among patients …

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Growth-accomodating implant for paediatric applications

A growth-accommodating implant for paediatric applications Feins E, et al. Medical implants of fixed size cannot accommodate normal tissue growth in children and often require eventual replacement or—in some cases—removal, leading to repeated interventions, increased complication rates and worse outcomes. Here, we report the design and use of a growth-accommodating device for paediatric applications that consists …

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Hacking risk leads to recall of 500,000 pacemakers

Hacking risk leads to recall of 500,000 pacemakers due to patient death fears the guardian FDA overseeing crucial firmware update in US to patch security holes and prevent hijacking of pacemakers implanted in half a million people. Almost half a million pacemakers have been recalled by the US Food and Drug Administration (FDA) due to …

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Incidence of Previously Undiagnosed Atrial Fibrillation Using Insertable Cardiac Monitors in a High-Risk Population

With the use of implanted cardiac monitors researchers found a substantial incidence (nearly 30 percent) of previously undiagnosed atrial fibrillation (AF) after 18 months in patients at high risk of both AF and stroke, according to a new study. Reiffel JA, Verma A, Kowey PR Results  A total of 446 patients were enrolled; 233 (52.2%) …

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More complications in heart valve surgery in the morning

Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study Montaigne D et al. Perioperative myocardial injury is transcriptionally orchestrated by the circadian clock in patients undergoing aortic valve replacement, and Rev-Erbα antagonism seems to be a pharmacological strategy for cardioprotection. …

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New pacemaker without battery

Neuartiger Herzschrittmacher ohne Batterie Bionity.com, XING-news Eine Mini-Turbine gewinnt aus dem Blutstrom ausreichend Energie, um einen Herzschrittmacher ohne Elektroden und ohne Batterie zu betreiben. Das torpedoförmige Implantat hat einen Durchmesser von 6,2 Millimetern. Über eine magnetische Kupplung treibt das Schaufelrad einen Mikrogenerator im Inneren des Gehäuses an und generiert so die benötigte elektrische Energie. Das …

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Outcomes for Absorb Stent Acceptable at One to Two Years, with Caveats

Patients receiving the Absorb everolimus-eluting bioresorbable vascular scaffold (BVS), a dissolving stent to open clogged vessels around the heart, showed outcomes comparable with patients receiving the Xience drug-eluting metal stent between years one and two. Ellis S However, patients receiving Absorb BVS faced an overall elevated risk of adverse outcomes at two years compared with …

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Study shows benefits to treating all clogged arteries at once after heart attack

Fractional Flow Reserve–Guided Multivessel Angioplasty in Myocardial Infarction Smits P et al. Patients experiencing a major heart attack often have more than one clogged artery, but under current guidelines doctors typically only clear the blockage responsible for the heart attack. Assessing and, when warranted, treating the additional blockages can improve patient outcomes and reduce the …

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Transcatheter Mitral Valve Technologies

Transcatheter Mitral Valve Technologies: The Heart of Cardiovascular Device Innovation Bawa TS, Hoffmann M, Thompson S, Kwei S The current atmosphere in medical device investment is one of caution: Over the last five years, about two-thirds of high-impact medical device M&A deals have occurred following U.S. commercialization1, that is, after targets had already generated the …

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