Heart valves that can grow with pediatric patients
17 March 2021
|There is a need for replacement heart valves that can grow with children. We fabricated tubes of fibroblast-derived collagenous matrix that have been shown to regenerate and grow as a pulmonary artery replacement (in lambs).
|The tri-tube valves demonstrated reduced calcification and improved hemodynamic function compared to clinically used pediatric bioprosthetic valves tested in the same model. This tri-tube valved conduit has potential for long-term valve growth in children.
|Syedain ZH, Haynie B, Johnson SL et al.
|Science Translational Medicine, Vol. 13, No 585, 17 Mar 2021, DOI: 10.1126/scitranslmed.abb7225
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