Thalamic deep brain stimulation in traumatic brain injury
a phase 1, randomized feasibility study
Converging evidence indicates that impairments in executive function and information-processing speed limit quality of life and social reentry after moderate-to-severe traumatic brain injury (msTBI). These deficits reflect dysfunction of frontostriatal networks for which the central lateral (CL) nucleus of the thalamus is a critical node. The primary objective of this feasibility study was to test the safety and efficacy of deep brain stimulation within the CL and the associated medial dorsal tegmental (CL/DTTm) tract.
|CL/DTTm deep brain stimulation can be safely applied and may improve executive control in patients with msTBI who are in the chronic phase of recovery.
|Schiff ND, Giacino JT, Butson CR et al.
|Nat Med (2023). https://doi.org/10.1038/s41591-023-02638-4
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