Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease
14 December 2022
|Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix.|
|Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement. On a local level, the optimal stimulation site resided at the direct interface between these structures. Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes. Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming.|
|Ríos AS, Oxenford S, Neudorfer C et al.||Nat Commun 13, 7707 (2022). https://doi.org/10.1038/s41467-022-34510-3|
|This is a post of a scientific or business information. The information given here is checked thoroughly by “Implant-Register”. However we can´t be responsible for the content. The content usually is shortened to make it understandable for many. Read the linked original text if you are interested. Contact the publisher, if you have questions. You may inform us about changes of the information to improve the Register.|
let us know
Find NEWS and PUBLICATIONS here according to your interests or use the search box.