NEWS-Material Supply

3d-printed Bone

Hyperelastic “bone”: A highly versatile, growth factor–free, osteoregenerative, scalable, and surgically friendly biomaterial Jakus A et al.  Despite substantial attention given to the development of osteoregenerative biomaterials, severe deficiencies remain in current products. These limitations include an inability to adequately, rapidly, and reproducibly regenerate new bone; high costs and limited manufacturing capacity; and lack of …

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3D-printed titanium mesh implants

Study shows how 3D printed titanium-mesh implants can be optimized for better bone regeneration Tess A collaborative research team from Harvard’s Wyss Institute, the Julius Wolff Institute, the Berlin-Brandenburg Center for Regenerative Therapies, and Charité’s Center for Musculoskeletal Surgery has come together to study the benefits of 3D printed titanium-mesh scaffolds in implants. The preclinical …

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BIOCOMPATIBILITY OF PLASTICS

  The International Organization for Standardization (ISO) presents widely adopted medical device guidelines that are aimed with a keen focus towards risk management. Biocompatibility testing for these devices and device components is addressed by ISO standard 10993. RESINATE 2017 Well-defined material characterization is a fundamental requirement in biocompatibility assessment. This evaluation consists of chemical, mechanical, …

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Cardiopatch for heart tissue

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues IY Shadrin et al. Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues for human therapy are lacking. Here we present a “Cardiopatch” platform for …

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Changes to ISO 13485 2016 for Medical Device Manufacturers, Designers

Published early in 2016, ISO 13485:2016 Medical devices — Quality management systems — Requirements for regulatory purposes establishes a new international framework to mitigate risk and produce effective medical devices. Christine Berard As the new standard now clarifies that a company’s QMS “shall meet customer and applicable regulatory requirements for safety and performance,” the time …

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Custom made subperiosteal oral implant enables to place definite fixed prosthesis in 6 weeks (german)

A custom made titanium subperiosteal mesh implant may help patients in hopeless cases. (german article) Gellrich N-C, Rahlf B The one-piece titanium fine-mesh implant is fixed with screws. Patients get a temporary denture for 6 weeks, thereafter a fixed bridge. This technique is helpful for elder or somehow sick patients, who are not willing to …

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Custom-milled individual allogeneic bone grafts for alveolar cleft osteoplasty – A technical note

  Surgeons from the Ludwig-Maximilians-University in Munich, Germany, showcase in this technical note the successful repair of an alveolar cleft using maxgraft® bonebuilder, an individualized allogeneic bone graft, in a 36-year old female patient with a 6-month-follow up showing good bony integration. Otto S et al. Today, bone grafts from the iliac crest are most …

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Efficacy of restorative brain–computer interfaces

Investigating the impact of feedback update interval on the efficacy of restorative brain–computer interfaces Royal Society open science. 4:170660. https://dx.doi.org/10.1098/rsos.170660 Restorative brain–computer interfaces (BCIs) have been proposed to enhance stroke rehabilitation. Restorative BCIs are able to close the sensorimotor loop by rewarding motor imagery (MI) with sensory feedback. Despite the promising results from early studies, …

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Esophageal Organoids from Human Pluripotent Stem Cells

Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification SL Trisno et al. Highlights • Sequential Wnt, RA, and BMP signaling are required to pattern dorsal anterior foregut • Cultured dorsal anterior foregut spheroids develop into esophageal organoids (HEOs) • HEOs contain basal esophageal progenitors and stratified squamous epithelium • Sox2 …

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Gentamicin coating of titanium alloy prevents implant-related osteomyelitis in rats

Gentamicin coating of plasma chemical oxidized titanium alloy prevents implant-related osteomyelitis in rats Biomaterials, Volume 101, issue 0, 156-164 Contamination of implants, bacterial load of bone powder and radiographic as well as histological signs of implant-related osteomyelitis were evaluated after four weeks. Gentamicin-SDS coating prevented implant contamination in 10 of 10 tibiae and gentamicin-tannic acid …

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Hydrophilicity, Viscoelastic, and Physicochemical Properties Variations in Dental Bone Grafting Substitutes

The indication-oriented Dental Bone Graft Substitutes (DBGS) selection, the correct bone defects classification, and appropriate treatment planning are very crucial for obtaining successful clinical results. Trajkovski B, Jaunich M, Müller W-D , Beuer F, Zafiropoulos G-G, Houshmand A We investigated the dimensional changes and molecular mobility by Dynamic Mechanical Analysis (DMA) of xenograft (cerabone®), synthetic (maxresorb®), …

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Implantable Artificial Kidney Could Enter Human Trials By 2017

A team of university scientists has developed the world’s first artificial kidney technology to be implanted in the body. Their bio-hybrid approach uses living kidney cells in tandem with a series of specialized microchips powered by the human heart to filter waste from the blood stream. The National Kidney Foundation estimates that over 100,000 patients …

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Nasal chondrocyte-based engineered autologous cartilage tissue

Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial Mumme M, Barbero A, Miot S, Wixmerten A, Feliciano S, Wolf F etal. Hyaline-like cartilage tissues, engineered from autologous nasal chondrocytes, can be used clinically for repair of articular cartilage defects in the knee. Future studies are warranted to …

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New pacemaker without battery

Neuartiger Herzschrittmacher ohne Batterie Bionity.com, XING-news Eine Mini-Turbine gewinnt aus dem Blutstrom ausreichend Energie, um einen Herzschrittmacher ohne Elektroden und ohne Batterie zu betreiben. Das torpedoförmige Implantat hat einen Durchmesser von 6,2 Millimetern. Über eine magnetische Kupplung treibt das Schaufelrad einen Mikrogenerator im Inneren des Gehäuses an und generiert so die benötigte elektrische Energie. Das …

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Osteogain® loaded onto an absorbable collagen sponge

Osteogain® loaded onto an absorbable collagen sponge induces attachment and osteoblast differentiation of ST2 cells in vitro. Miron et al. RESULTS: ACS efficiently loaded nearly 100% of the amelogenin proteins found in Osteogain® which were gradually released up to a 10-day period. Osteogain® also significantly induced a 1.5-fold increase in cell attachment and resulted in …

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Reliability In Medical Electronic Devices

Redefining Reliability In Medical Electronic Devices Subrahmanyan R, Sporon-Fiedler F, Primavera A, Shen D Micro Systems Engineering (MSEI), a subsidiary of Micro Systems Technologies (MST), has developed a systematic, end-to-end advanced reliability methodology (e2ARM) that focuses on the application of reliability technologies throughout a device’s lifecycle MED DEVICE ONLINE July 20,2016 This is a post …

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Robotic System for Dental Implants

FDA Clears First Robotic System For Dental Implant Procedures MED DEVICE ONLINE The FDA has approved “game-changing” technology that provides pre-operative and intra-operative guidance for surgeons performing dental implant procedures. The robotic navigation system from Neocis — called Yomi — can reduce surgery time and improve accuracy compared to procedures performed free-hand, said Neocis CEO …

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Silica sol-gel hybrid coatings for metal implants

Control of the degradation of silica sol-gel hybrid coatings for metal implants prepared by the triple combination of alkoxysilanes Romero-Gavilán F, Barros-Silva S,  García-Canadas J, Palla B, Izquierdo R, Gurruchaga M, Goñi M, Suay J Development of new hybrid sol-gel coatings based on triple mixtures of alkoxysilanesTEOS alkoxysilane ability to tune sol-gel DegradationProtective behavior of MTMOS:GPTMS:TEOS coatingsA compromise between metal protection and silica sol-gel …

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Tissue-engineered intervertebral disc implant

Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc Gullbrand SE, Ashinsky BG, Bonnevie ED et al. Intervertebral disc degeneration causes back and neck pain, sometimes necessitating disc fusion surgery. Although fusion may alleviate symptoms, it does not address the underlying cause of degeneration. As an alternative to fusion, Gullbrand and colleagues developed …

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Total Knee Replacement – Computer-Assisted versus Conventional

Computer-Assisted Compared with Conventional Total Knee Replacement G Petursson et al. In this study, the use of computer navigation provided better pain relief and restored better function than the use of the conventional surgical technique at 2 years after total knee replacement. The Journal of Bone and Joint Surgery, 2018 Aug 1; 100 (15): 1265, …

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US scientists design an artificial kidney with Nano filters that could replace dialysis

The artificial kidney, about to enter its testing phase in humans, will combine electronic and organic elements, and will be similar in size to organs whose function it will assume. This will be a huge improvement for the lives of those who need to connect several times a week to an external hemodialysis device because …

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Use of Collagen, PTFE and PRF Membranes in Bone Reconstruction

Use of Collagen, PTFE and PRF Membranes in Bone Reconstruction an Experimental and Histomorphometric Study Neculae et al. In the present study it can be noted that bone regeneration differs depending on the type of barrier membranes used. There is an advantage of collagen membranes compared to non-resorbable d-PTFE membranes. The use of PRF membrane

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Wireless bioresorbable electronic system

Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy Koo J, MacEwan MR, Rogers JA Peripheral nerve injuries represent a significant problem in public health, constituting 2–5% of all trauma cases. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory function. Numerous studies report the …

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World´s first implantable artificial kidney

World’s First Implantable Artificial Kidney Could Enter Human Trials By 2017 Suzanne Hodsden A team of university scientists has developed the world’s first artificial kidney technology to be implanted in the body. Their bio-hybrid approach uses living kidney cells in tandem with a series of specialized microchips powered by the human heart to filter waste …

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Xenogeneic bone grafting materials

Nowadays, a variety of bone substitutes are available for the clinical user. Interestingly, these materials significantly differ regarding their raw materials or manufacturing processes. As an alternative to autologous bone tissue (autograft), which is still applied as “gold standard” due to its extensive regenerative properties, bone substitutes from other natural sources become more and more …

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