NEWS on implant material, supply

3D bioprinting rebuilding components of the human heart

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3D eye cells printed for the first time

A group of researchers from the UK have used 3-D biomedical printing to successfully print new eye cells www.3ders.org The ability to arrange cells into highly defined patterns and structures has recently elevated the use of 3D printing in the biomedical sciences to create cell-based structures for use in regenerative...

3D printing for hearing devices

3D printing assists implantation of hearing device A Kim "In all three cases, quick identification of the appropriate [bone implant] position was accomplished," they wrote. "The transparent template enabled safe identification of the planned [bone implant] position on the temporal bone, previously localized on the 3D-printed model." AuntMinnie, 4 Dec...

3D Printing of Heart

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3D printing of soft robotic systems

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3D Printing Plasma Jetting Method for Bone Implants

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3D printing rapidly developing in life sciences

The “3D Printing for Life Sciences 2018” symposium topics: bioprinting, the medical devices industry and medical 3D printing.  Sebastien Meunier Printing skin, muscle tissue or bone matter is already a reality, but you can’t yet print an organ, even though things are heading in that direction. Basel Area Innovation Report...

3D printing technologies for soft and hard tissue regeneration

Typically, manufacturing technology is done in four steps: creating or scanning, converting to a file, specifying the print material, and manufacturing. The production of artificial tissues using 3D printing is known as bioprinting. The most common method is the top-down approach. Recently, the bottom-up proceeding has also been successful. Certain...

3D printing technology could save animal testing

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3d-printed Bone

Hyperelastic “bone”: A highly versatile, growth factor–free, osteoregenerative, scalable, and surgically friendly biomaterial Jakus A et al.  Despite substantial attention given to the development of osteoregenerative biomaterials, severe deficiencies remain in current products. These limitations include an inability to adequately, rapidly, and reproducibly regenerate new bone; high costs and limited...

3D-printed titanium mesh implants

Study shows how 3D printed titanium-mesh implants can be optimized for better bone regeneration Tess A collaborative research team from Harvard’s Wyss Institute, the Julius Wolff Institute, the Berlin-Brandenburg Center for Regenerative Therapies, and Charité’s Center for Musculoskeletal Surgery has come together to study the benefits of 3D printed titanium-mesh...

Anti-Inflammatory Activity of Heparin- and Hyaluronan-Containing Multilayer Coatings

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Avoid Compliance & Timeline Risks Whith Medical Device Supplier

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Bio-functionalization of grade V titanium alloy with human type I human collagen

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BIOCOMPATIBILITY OF PLASTICS

  The International Organization for Standardization (ISO) presents widely adopted medical device guidelines that are aimed with a keen focus towards risk management. Biocompatibility testing for these devices and device components is addressed by ISO standard 10993. RESINATE 2017 Well-defined material characterization is a fundamental requirement in biocompatibility assessment. This...

Bioprinting- 3D printing of lung scaffolds

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Bioprinting: Where do your bones come from?

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Bone growth inspired “microrobots” that can create their own bone

Inspired by the growth of bones in the skeleton, researchers at the universities of Linköping in Sweden and Okayama in Japan have developed a combination of materials that can morph into various shapes before hardening. The material is initially soft, but later hardens through a bone development process that uses...

Bone tissue engeneering via ultrasound-mediated gene delivery

In situ bone tissue engeneering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs Bez, Maxim, et al. Science Journal University of Leicester, Amgen, ORTHOfilms Science Translational Medicin 9.390 (2017)

Cardiopatch for heart tissue

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues IY Shadrin et al. Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for drug development and disease modeling studies, methods to generate large, functional heart tissues for human therapy are lacking. Here we...

Changes to ISO 13485 2016 for Medical Device Manufacturers, Designers

Published early in 2016, ISO 13485:2016 Medical devices — Quality management systems — Requirements for regulatory purposes establishes a new international framework to mitigate risk and produce effective medical devices. Christine Berard As the new standard now clarifies that a company’s QMS “shall meet customer and applicable regulatory requirements for...

Custom made subperiosteal oral implant enables to place definite fixed prosthesis in 6 weeks (german)

A custom made titanium subperiosteal mesh implant may help patients in hopeless cases. (german article) Gellrich N-C, Rahlf B The one-piece titanium fine-mesh implant is fixed with screws. Patients get a temporary denture for 6 weeks, thereafter a fixed bridge. This technique is helpful for elder or somehow sick patients,...

Custom-made silicone heart valves

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Custom-milled individual allogeneic bone grafts for alveolar cleft osteoplasty – A technical note

  Surgeons from the Ludwig-Maximilians-University in Munich, Germany, showcase in this technical note the successful repair of an alveolar cleft using maxgraft® bonebuilder, an individualized allogeneic bone graft, in a 36-year old female patient with a 6-month-follow up showing good bony integration. Otto S et al. Today, bone grafts from...

Efficacy of restorative brain–computer interfaces

Investigating the impact of feedback update interval on the efficacy of restorative brain–computer interfaces Royal Society open science. 4:170660. https://dx.doi.org/10.1098/rsos.170660 Restorative brain–computer interfaces (BCIs) have been proposed to enhance stroke rehabilitation. Restorative BCIs are able to close the sensorimotor loop by rewarding motor imagery (MI) with sensory feedback. Despite the...

Esophageal Organoids from Human Pluripotent Stem Cells

Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification SL Trisno et al. Highlights • Sequential Wnt, RA, and BMP signaling are required to pattern dorsal anterior foregut • Cultured dorsal anterior foregut spheroids develop into esophageal organoids (HEOs) • HEOs contain basal esophageal progenitors and...

Gentamicin coating of titanium alloy prevents implant-related osteomyelitis in rats

Gentamicin coating of plasma chemical oxidized titanium alloy prevents implant-related osteomyelitis in rats Biomaterials, Volume 101, issue 0, 156-164 Contamination of implants, bacterial load of bone powder and radiographic as well as histological signs of implant-related osteomyelitis were evaluated after four weeks. Gentamicin-SDS coating prevented implant contamination in 10 of...

Hydrophilicity, Viscoelastic, and Physicochemical Properties Variations in Dental Bone Grafting Substitutes

The indication-oriented Dental Bone Graft Substitutes (DBGS) selection, the correct bone defects classification, and appropriate treatment planning are very crucial for obtaining successful clinical results. Trajkovski B, Jaunich M, Müller W-D , Beuer F, Zafiropoulos G-G, Houshmand A We investigated the dimensional changes and molecular mobility by Dynamic Mechanical Analysis (DMA)...

Hyperelastic “bone”

Hyperelastic “bone”: A highly versatile, growth factor–free, osteoregenerative, scalable, and surgically friendly biomaterial Adam EJ et al What if we could create custom bone implants that would trigger their own replacement with real bone? Jakus and colleagues have done just this with a promising biomaterial that can be 3D-printed into...

Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 1: description of the Implant Surface Identification Standard (ISIS) codification system

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Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 2: anodized and Titanium Plasma-Sprayed (TPS) surfaces (Group 1, metallurgy modification)

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Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 3: sand-blasted/acid-etched (SLA type) and related surfaces (Group 2A, main subtractive process)

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Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 4: Resorbable Blasting Media (RBM), Dual Acid-Etched (DAE), Subtractive Impregnated Micro/Nanotextured (SIMN) and related surfaces (Group 2B, other subtractive process)

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Identification card and codification of the chemical and morphological characteristics of 62 dental implant surfaces. Part 5: chemically coated surfaces (Group 3, coating) and implant collar surfaces (Group 4, collar)

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implant files

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Implantable Artificial Kidney Could Enter Human Trials By 2017

A team of university scientists has developed the world’s first artificial kidney technology to be implanted in the body. Their bio-hybrid approach uses living kidney cells in tandem with a series of specialized microchips powered by the human heart to filter waste from the blood stream. The National Kidney Foundation...

Implantable Silicone

The use of implantable Silicone in medical devices sponsored After more than 50 years of using silicone rubber in medical implants, the number of applications for the material’s use in both short- and long-term implantable medical devices just keeps growing. With its long track record of biocompatibility, medical-grade silicone is...

In laboratory breeded bone implanted

In Israel (Haifa) inlab breeded bone has been implanted to bridge 4cm bone defect in tibia Rozen N Bone was generated from patient´s fat cells and stem cells. Bone formation took two month. The process was developed by Bonus Biogroup. dpa/Dtsch Ärzteblatt

Influence of hydrogel coatings on corrosion and fatigue of iron in simulated body fluid

Surface corrosion and fatigue studies of pure iron were performed in a modified simulated body fluid (m-SBF) electrolyte with and without applied agar films as a typical hydrogel film. The electrochemical corrosion rates were analysed using electrochemical impedance spectroscopy. The morphology and surface chemical composition of the samples after exposure...

Medical Device Manufacturing Using Automation And A Digital Factory

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Metal-Specific Biomaterial Accumulation in Human Peri-Implant Bone and Bone Marrow

Metallic implants are frequently used in medicine to support and replace degenerated tissues. Implant loosening due to particle exposure remains a major cause for revision arthroplasty. The exact role of metal debris in sterile peri-implant inflammation is controversial, as it remains unclear whether and how metals chemically alter and potentially...

Metals Used in Medical Devices

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Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation

Nanoparticles are increasingly used in various fields, including biomedicine and electronics. One application utilizes the opacifying effect of nano-TiO2, which is frequently used as pigment in cosmetics. Although TiO2 is believed to be biologically inert, an emerging literature reports increased incidence of respiratory diseases in people exposed to TiO2. Thus,...

Nasal chondrocyte-based engineered autologous cartilage tissue

Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial Mumme M, Barbero A, Miot S, Wixmerten A, Feliciano S, Wolf F etal. Hyaline-like cartilage tissues, engineered from autologous nasal chondrocytes, can be used clinically for repair of articular cartilage defects in the knee....

New pacemaker without battery

Neuartiger Herzschrittmacher ohne Batterie Bionity.com, XING-news Eine Mini-Turbine gewinnt aus dem Blutstrom ausreichend Energie, um einen Herzschrittmacher ohne Elektroden und ohne Batterie zu betreiben. Das torpedoförmige Implantat hat einen Durchmesser von 6,2 Millimetern. Über eine magnetische Kupplung treibt das Schaufelrad einen Mikrogenerator im Inneren des Gehäuses an und generiert so...

Organs derived from donor pluripotent stem cells using a xenogenic environment

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Organs in miniature format

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Organs in miniature format

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Osteogain® loaded onto an absorbable collagen sponge

Osteogain® loaded onto an absorbable collagen sponge induces attachment and osteoblast differentiation of ST2 cells in vitro. Miron et al. RESULTS: ACS efficiently loaded nearly 100% of the amelogenin proteins found in Osteogain® which were gradually released up to a 10-day period. Osteogain® also significantly induced a 1.5-fold increase in...

Poietis Automates the Manufacturing of Biological Tissue

While the manufacturing of biological tissue meets major societal demands, it also faces significant challenges related to process standardization and scaling up. With these challenges in mind, the French start-up Poietis has developed the Next Generation Bioprinting (NGB) platform to achieve 4D bioprinting of biological tissue in a faster, more affordable and more functional...

Polymeric Materials And Coronary Angioplasty Devices

Cardiovascular diseases are responsible for over 15 million deaths worldwide per year.1 The occlusion of vessels such as the coronary or peripheral arteries hinders the flow of blood to the heart, resulting in heart attacks (myocardial infarction) and often death. Percutaneous transluminal coronary angioplasty (PTCA), a minimally invasive endovascular procedure...

Reduction of biofilm formation on titanium surface with ultraviolet-C pre-irradiation

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Reliability In Medical Electronic Devices

Redefining Reliability In Medical Electronic Devices Subrahmanyan R, Sporon-Fiedler F, Primavera A, Shen D Micro Systems Engineering (MSEI), a subsidiary of Micro Systems Technologies (MST), has developed a systematic, end-to-end advanced reliability methodology (e2ARM) that focuses on the application of reliability technologies throughout a device’s lifecycle MED DEVICE ONLINE July...

Robotic System for Dental Implants

FDA Clears First Robotic System For Dental Implant Procedures MED DEVICE ONLINE The FDA has approved “game-changing” technology that provides pre-operative and intra-operative guidance for surgeons performing dental implant procedures. The robotic navigation system from Neocis — called Yomi — can reduce surgery time and improve accuracy compared to procedures...

Self-charging pacemaker

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Silica sol-gel hybrid coatings for metal implants

Control of the degradation of silica sol-gel hybrid coatings for metal implants prepared by the triple combination of alkoxysilanes Romero-Gavilán F, Barros-Silva S,  García-Canadas J, Palla B, Izquierdo R, Gurruchaga M, Goñi M, Suay J Development of new hybrid sol-gel coatings based on triple mixtures of alkoxysilanesTEOS alkoxysilane ability to tune sol-gel DegradationProtective behavior of MTMOS:GPTMS:TEOS coatingsA compromise between...

Soft Robotics: Fluid‐Driven Intrinsically Soft Devices

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The world’s smallest stent

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Tissue-engineered intervertebral disc implant

Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc Gullbrand SE, Ashinsky BG, Bonnevie ED et al. Intervertebral disc degeneration causes back and neck pain, sometimes necessitating disc fusion surgery. Although fusion may alleviate symptoms, it does not address the underlying cause of degeneration. As an alternative to...

Total Knee Replacement – Computer-Assisted versus Conventional

Computer-Assisted Compared with Conventional Total Knee Replacement G Petursson et al. In this study, the use of computer navigation provided better pain relief and restored better function than the use of the conventional surgical technique at 2 years after total knee replacement. The Journal of Bone and Joint Surgery, 2018...

US scientists design an artificial kidney with Nano filters that could replace dialysis

The artificial kidney, about to enter its testing phase in humans, will combine electronic and organic elements, and will be similar in size to organs whose function it will assume. This will be a huge improvement for the lives of those who need to connect several times a week to...

US to Investigate Health Impact of Nickel, Silicone in Medical Implants

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Use of Collagen, PTFE and PRF Membranes in Bone Reconstruction

Use of Collagen, PTFE and PRF Membranes in Bone Reconstruction an Experimental and Histomorphometric Study Neculae et al. In the present study it can be noted that bone regeneration differs depending on the type of barrier membranes used. There is an advantage of collagen membranes compared to non-resorbable d-PTFE membranes....

When the pacemaker is hacked

Cybercrime against healthcare facilities is on the rise, and the networking of medical devices opens up numerous gateways for hackers. To protect patients and facilities, all players must cooperate, and the manufacturers of medical devices have a special role to play. Modern hospitals and other healthcare facilities depend on functioning...

Wi-Fi-band wireless energy harvesting

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Wireless bioresorbable electronic system

Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy Koo J, MacEwan MR, Rogers JA Peripheral nerve injuries represent a significant problem in public health, constituting 2–5% of all trauma cases. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory...

World´s first implantable artificial kidney

World's First Implantable Artificial Kidney Could Enter Human Trials By 2017 Suzanne Hodsden A team of university scientists has developed the world’s first artificial kidney technology to be implanted in the body. Their bio-hybrid approach uses living kidney cells in tandem with a series of specialized microchips powered by the...

Xenogeneic bone grafting materials

Nowadays, a variety of bone substitutes are available for the clinical user. Interestingly, these materials significantly differ regarding their raw materials or manufacturing processes. As an alternative to autologous bone tissue (autograft), which is still applied as “gold standard” due to its extensive regenerative properties, bone substitutes from other natural...