Organs derived from donor pluripotent stem cells using a xenogenic environment

Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem CellsKobayashi T et al.
The complexity of organogenesis hinders in vitro generation of organs derived from a patient’s pluripotent stem cells (PSCs), an ultimate goal of regenerative medicine.

These data constitute proof of principle for interspecific blastocyst complementation and for generation in vivo of organs derived from donor PSCs using a xenogenic environment.

Cell, Vol 142, 5, P787-799, Sep 03, 2010
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