Xenogeneic bone grafting materials

Nowadays, a variety of bone substitutes are available for the clinical user. Interestingly, these materials significantly differ regarding their raw materials or manufacturing processes. As an alternative to autologous bone tissue (autograft), which is still applied as “gold standard” due to its extensive regenerative properties, bone substitutes from other natural sources become more and more relevant in regenerative dentistry. These bone substitute materials are either derived from human (allograft) or animal origin (xenograft).
In case of these materials, the obtained bony
extracellular matrix based on calcium phosphates should finally serve as bone substitute. Based on the physicochemical similarity of this class of bone substitutes to the autologous bone tissue, it can be assumed that these materials are the ideal choice for osseous regeneration. Preferentially, bovine bone is used as source tissue in the daily dental practice, as in case of the two primarily applied bone substitute materials Bio-Oss™ and cerabone®.
Barbeck M, Unger R, Witte F, Wenisch S, Schnettler R
Altogether, it can be concluded that the xenogeneic bone substitute material cerabone® is able to ensure the highest possible safety from disease transmission due to the high temperature treatment. Furthermore, it is assumable that the relatively high numbers of multinucleated giant cells express high amounts of antiinflammatory molecules and support a fast and high implant bed vascularisation and therefore, might favour the bone regeneration process._implants 3/ 2017, 34-36
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