Esophageal Organoids from Human Pluripotent Stem Cells

Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal SpecificationSL Trisno et al.

Highlights

Sequential Wnt, RA, and BMP signaling are required to pattern dorsal anterior foregut

Cultured dorsal anterior foregut spheroids develop into esophageal organoids (HEOs)

HEOs contain basal esophageal progenitors and stratified squamous epithelium

Sox2 is sufficient to repress the respiratory fate by suppressing Wnt signaling

ScienceDirect 4 Oct 2018
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