Esophageal Organoids from Human Pluripotent Stem Cells

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Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification SL Trisno et al.

Highlights

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Sequential Wnt, RA, and BMP signaling are required to pattern dorsal anterior foregut

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Cultured dorsal anterior foregut spheroids develop into esophageal organoids (HEOs)

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HEOs contain basal esophageal progenitors and stratified squamous epithelium

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Sox2 is sufficient to repress the respiratory fate by suppressing Wnt signaling

 ScienceDirect 4 Oct 2018
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