NEWS on nervous system implants

Biomimetic 3D-printed scaffolds for spinal injury repair

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Brain implant enables ALS patients to communicate with the world outside

A patient in the advanced stages of amyotrophic lateral sclerosis (ALS) who had lost his last ability to communicate with the outside world after paralyzing his eye muscles has learned to make himself heard again with the help of a brain-computer interface. Nach dem in Nature Communications (2022; DOI: 10.1038/s41467-022-28859-8) vorgestellten Fall­bericht konnte...

Closed-loop neuromodulation in an individual with treatment-resistant depression

Deep brain stimulation is a promising treatment for neuropsychiatric conditions such as major depression. Closed-loop therapy resulted in a rapid and sustained improvement in depression. Future work is required to determine if the results and approach of this n-of-1 study generalize to a broader population. Author(s) Source Scangos KW, Khambhati AN,...

Efficacy of restorative brain–computer interfaces

Investigating the impact of feedback update interval on the efficacy of restorative brain–computer interfaces Royal Society open science. 4:170660. https://dx.doi.org/10.1098/rsos.170660 Restorative brain–computer interfaces (BCIs) have been proposed to enhance stroke rehabilitation. Restorative BCIs are able to close the sensorimotor loop by rewarding motor imagery (MI) with sensory feedback. Despite the...

Foramen Ovale Closure after Stroke

Among adults who had had a cryptogenic ischemic stroke, closure of a PFO was associated with a lower rate of recurrent ischemic strokes than medical therapy alone during extended follow-up. (Funded by St. Jude Medical; RESPECT ClinicalTrials.gov number, NCT00465270.) Supported by St. Jude Medical. N Engl J Med 2017; 377:1022-1032September...

High-performance brain-to-text communication via handwriting

Brain–computer interfaces (BCIs) can restore communication to people who have lost the ability to move or speak. So far, a major focus of BCI research has been on restoring gross motor skills, such as reaching and grasping or point-and-click typing with a computer cursor. However, rapid sequences of highly dexterous...

Implanted System for Orthostatic Hypotension in Multiple-System Atrophy

Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood pressure and enable a patient with multiple-system atrophy to stand and walk after having...

Medical device that treats pain shocks, burns patients

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Medtronic launches InterStim neurostim leads in U.S.

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Nerve stimulation with the help of implantable mini solar cells

An international research team has successfully developed and tested a concept in which nerves are stimulated with light pulses. The method provides considerable advantages for medicine and opens up a wide range of possible applications. The researchers see possible applications in severe brain injuries. Here, the stimulation of nerve cells...

Neural Bypass Technology

Battelle NeuroLife™ Neural Bypass Technology Batelle Battelle has developed a breakthrough technology that empowers paralyzed patients to regain conscious control of their fingers, hand and wrist. The Battelle NeuroLife Neural Bypass Technology skips damaged areas of the nervous system to allow the brain to communicate directly with muscles. Med Device...

Neural decoding of spoken sentences

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Neuromodulation of lumbosacral spinal networks after complete paraplegia

Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia L Megan et al. Spinal sensorimotor networks that are functionally disconnected from the brain because of spinal cord injury (SCI) can be facilitated via epidural electrical stimulation (EES) to restore robust, coordinated motor activity in humans with paralysis1,2,3. Previously,...

Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria

Technology to restore the ability to communicate in paralyzed persons who cannot speak has the potential to improve autonomy and quality of life. An approach that decodes words and sentences directly from the cerebral cortical activity of such patients may represent an advancement over existing methods for assisted communication. In...

Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria

Technology to restore the ability to communicate in paralyzed persons who cannot speak has the potential to improve autonomy and quality of life. An approach that decodes words and sentences directly from the cerebral cortical activity of such patients may represent an advancement over existing methods for assisted communication. We...

Novel brain pacemaker first used for the treatment of obsessive-compulsive disorder (OCD)

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Parkinson’s disease: Better overall behavioural outcomes with bilateral subthalamic stimulation plus medical therapy

Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial Lhommée E et al. In a large cohort with Parkinson's disease and early motor complications, better overall behavioural outcomes were noted with...

Phrenic nerve stimulation for the treatment of central sleep apnea

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Restorative Neurostimulation to Activate the Lumbar Multifidus

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Spelling interface using intracortical signals enabled neurofeedback training

Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means of communication. Here, we implanted two 64 microelectrode...

Spinal chord stimulators (implant files)

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Spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Three people once paralysed by complete spinal-cord injuries can walk, swim, work the pedals of a bicycle and even paddle canoes, thanks to an implant that stimulates neurons in their spinal cords. Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord...

Tongue pacemaker which allows MRT

A new system of tongue pacemaker which allows to make MRT was implanted at University Clinic, Innsbruck, Austria Schwamberger The first tongue pacemaker was implanted in 2015 to treat a certain sleep apnoea. The former system did not allow MRT because of strong magnet field. The new system solves this...

Vagus nerve stimulation paired with rehabilitation for upper limb motor function…

Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial Long-term loss of arm function after ischaemic stroke is common and might be improved by vagus nerve stimulation paired with rehabilitation. We aimed to determine whether this strategy is...

Wireless bioresorbable electronic system

Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy Koo J, MacEwan MR, Rogers JA Peripheral nerve injuries represent a significant problem in public health, constituting 2–5% of all trauma cases. For severe nerve injuries, even advanced forms of clinical intervention often lead to incomplete and unsatisfactory motor and/or sensory...