Spelling interface using intracortical signals enabled neurofeedback training
Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training
Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means of communication.
|Here, we implanted two 64 microelectrode arrays in the supplementary and primary motor cortex of a patient in a completely locked-in state with ALS. The patient modulated neural firing rates based on auditory feedback and he used this strategy to select letters one at a time to form words and phrases to communicate his needs and experiences. This case study provides evidence that brain-based volitional communication is possible even in a completely locked-in state.|
|Chaudhary U, Vlachos J, Zimmermann JB et al.||nature communications 13, Article number: 1236 (2022)
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