Parkinson’s disease: Better overall behavioural outcomes with bilateral subthalamic stimulation plus medical therapy

Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson’s disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trialLhommée E et al.
In a large cohort with Parkinson’s disease and early motor complications, better overall behavioural outcomes were noted with bilateral subthalamic stimulation plus medical therapy compared with medical therapy alone. The presence of hyperdopaminergic behaviours and neuropsychiatric fluctuations can be judged additional arguments in favour of subthalamic stimulation if surgery is considered for disabling motor complications.The Lancet, Vol 17, No. 3, p223-231

DOI: https://doi.org/10.1016/S1474-4422(18)30035-8

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