Biomimetic 3D-printed scaffolds for spinal injury repair
15 January 2019
|We report the use of a microscale continuous projection printing method (μCPP) to create a complex CNS structure for regenerative medicine applications in the spinal cord.||Koffler J, et al|
|We find that injured host axons regenerate into 3D biomimetic scaffolds and synapse onto NPCs implanted into the device and that implanted NPCs in turn extend axons out of the scaffold and into the host spinal cord below the injury to restore synaptic transmission and significantly improve functional outcomes. Thus, 3D biomimetic scaffolds offer a means of enhancing CNS regeneration through precision medicine.||nature medicine, 14 Jan 2019, DOI https://doi.org/10.1038/s41591-018-0296-z|
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