bioprinting tissue-like constructs capable of controlled, complex shape change

Where standard 3D printing uses a digital blueprint to manufacture an object out of materials like plastic or resin, 3D bioprinting manufactures biological parts and tissues out of living cells, or bioinks. A fourth dimension — shape transformation over time — can be achieved by incorporating materials that enable printed constructs to morph multiple times in a preprogrammed or on-demand manner in response to external signals.

Bioprinting 4D constructs provides opportunities for scientists to better mimic the shape changes that occur during the development, healing and normal function of real tissues and fabricate complex structures.

This bioink system provides the opportunity to print bioconstructs capable of achieving more sophisticated architectural changes over time than was previously possible. These cell-rich structures with pre-programmable and controllable shape morphing promise to better mimic the body’s natural developmental processes and could help scientists conduct more accurate studies of tissue morphogenesis and achieve greater advances in tissue engineering,” said study corresponding author Eben Alsberg
Author(s)Source
Carey JUniversity of Illinois Chicago, 04.04.2022
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