Spelling interface using intracortical signals enabled neurofeedback training

28 March 2022

Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means of communication.
Here, we implanted two 64 microelectrode arrays in the supplementary and primary motor cortex of a patient in a completely locked-in state with ALS. The patient modulated neural firing rates based on auditory feedback and he used this strategy to select letters one at a time to form words and phrases to communicate his needs and experiences. This case study provides evidence that brain-based volitional communication is possible even in a completely locked-in state.
Author(s)	Source
Chaudhary U, Vlachos J, Zimmermann JB et al.	nature communications 13, Article number: 1236 (2022) https://doi.org/10.1038/s41467-022-28859-8
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