Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation
09 November 2010
| Nanoparticles are increasingly used in various fields, including biomedicine and electronics. One application utilizes the opacifying effect of nano-TiO2, which is frequently used as pigment in cosmetics. Although TiO2 is believed to be biologically inert, an emerging literature reports increased incidence of respiratory diseases in people exposed to TiO2. |
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| Thus, the inflammation caused by nano-TiO2 in vivo is largely caused by the biological effect of IL-1α. The current use of nano-TiO2 may present a health hazard due to its capacity to induce IL-1R signaling, a situation reminiscent of inflammation provoked by asbestos exposure. |
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| Author(s) | Source |
| Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J Department of Biochemistry, University of Lausanne |
PNAS | November 9, 2010 | vol. 107 | no. 45 | 19449–19454 |
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