Guided bone regeneration of bone defects using a TiO2 scaffold

Guided bone regeneration of chronic non‐contained bone defects using a volume stable porous block TiO2 scaffold: An experimental in vivo study


To evaluate new lateral bone formation and lateral volume augmentation by guided bone regeneration (GBR) in chronic non‐contained bone defects with the use of a non‐resorbable TiO2‐block.

Materials and methods

Three buccal bone defects were created in each hemimandible of eight beagle dogs and allowed to heal for 8 weeks before treatment by GBR.


The TiO2 blocks rendered the largest lateral volume augmentation but also less new bone formation compared with the DBBM particles. The most new lateral bone formation outward from the bone defect margins was observed in the empty controls, indicating that the presence of either graft material leads to slow appositional bone growth.

Author(s) Source
Le Thieu MK, Haugen HJ, Sanz-Esporrin J et al. Clinical Oral Implant Research, Vol 32, Issue3, March 2021, 369-381,
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