Axial alignment is a critical regulator of knee osteoarthritis
25 February 2022
|Although osteoarthritis (OA), a leading cause of disability, has been associated with joint malalignment, scientific translational evidence for this link is lacking. In a clinical case study, we provide evidence of osteochondral recovery upon unloading symptomatic isolated medial tibiofemoral knee OA associated with varus malalignment.|
|Therapeutic unloading shifted the articular cartilage and subchondral bone phenotype to normal and restored several physiological correlations disturbed in neutral and varus OA, suggesting a protective effect on the integrity of the entire osteochondral unit. Collectively, these findings identify modifiable trajectories with considerable translational potential to reduce the burden of human OA.
Thus, a repositioning osteotomy could avoid joint replacement.
|Olah T, Reinhard J, Laschke MW et al.||SCIENCE TRANSLATIONAL MEDICINE • 26 Jan 2022 • Vol 14, Issue 629 • DOI: 10.1126/scitranslmed.abn0179|
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