Axial alignment is a critical regulator of knee osteoarthritis

25 February 2022

Although osteoarthritis (OA), a leading cause of disability, has been associated with joint malalignment, scientific translational evidence for this link is lacking. In a clinical case study, we provide evidence of osteochondral recovery upon unloading symptomatic isolated medial tibiofemoral knee OA associated with varus malalignment.
Therapeutic unloading shifted the articular cartilage and subchondral bone phenotype to normal and restored several physiological correlations disturbed in neutral and varus OA, suggesting a protective effect on the integrity of the entire osteochondral unit. Collectively, these findings identify modifiable trajectories with considerable translational potential to reduce the burden of human OA. Thus, a repositioning osteotomy could avoid joint replacement.
Author(s)	Source
Olah T, Reinhard J, Laschke MW et al.	SCIENCE TRANSLATIONAL MEDICINE • 26 Jan 2022 • Vol 14, Issue 629 • DOI: 10.1126/scitranslmed.abn0179
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