Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD
20 October 2025
| Geographic atrophy due to age-related macular degeneration (AMD) is the leading cause of irreversible blindness and affects more than 5 million persons worldwide. No therapies to restore vision in such persons currently exist. The photovoltaic retina implant microarray (PRIMA) system combines a subretinal photovoltaic implant and glasses that project near-infrared light to the implant in order to restore sight to areas of central retinal atrophy. | |
| In this study involving 38 participants with geographic atrophy due to AMD, the PRIMA system restored central vision and led to a significant improvement in visual acuity from baseline to month 12. (Funded by Science Corporation and the Moorfields National Institute for Health and Care Research Biomedical Research Centre; PRIMAvera ClinicalTrials.gov number) | |
| Author(s) | Source |
| Frank G. Holz, M.D., Yannick Le Mer, M.D., Mahiul M.K. Muqit, M.D., Ph.D., Lars-Olof Hattenbach, M.D., Ph.D., Andrea Cusumano, M.D., Ph.D., Salvatore Grisanti, M.D., Laurent Kodjikian, M.D., Ph.D., +17 , and José-Alain Sahel, M.D. | The New England Journal of Medicine,
N Engl J Med 2026;394:232-242,
DOI: 10.1056/NEJMoa2501396
VOL. 394 NO. 3
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