Regeneration therapy for lost teeth

Tooth loss is a widespread problem in adults and results in poor quality of life. Currently, solutions to this problem include artificial teeth and implants. But these aren’t as good as “real teeth,” and they don’t markedly improve quality of life. Now, scientists from Japan have made a discovery that can make re-growing teeth possible. They found, with animal studies, that suppressing the gene USAG-1 by using its antibody can efficiently lead to tooth growth.
Experiments with this antibody revealed that BMP signaling is essential for determining the number of teeth in mice.

The study is the first to show the benefits of monoclonal antibodies on tooth regeneration and provides a new therapeutic framework for a clinical problem that can currently only be resolved with implants and other artificial measures.

Our results demonstrate that USAG-1 controls the number of teeth by inhibiting development of potential tooth germs in wild-type or mutant mice missing teeth. Anti–USAG-1 antibody administration is, therefore, a promising approach for tooth regeneration therapy.

Author(s)Source
Murashima-Suginami A, Kiso H, Tokita Y et al.Science Advances  12 Feb 2021: Vol. 7, no. 7, eabf1798
DOI: 10.1126/sciadv.abf1798
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