|Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT)
|The use of transvaginal mesh and biological graft material in prolapse surgery is controversial and has led to a number of enquiries into their safety and eﬃcacy. Existing trials of these augmentations are individually too small to be conclusive. We aimed to compare the outcomes of prolapse repair involving either synthetic mesh inlays or biological grafts against standard repair in women.
Augmentation of a vaginal repair with mesh or graft material did not improve women’s outcomes in terms of eﬀectiveness, quality of life, adverse eﬀects, or any other outcome in the short term, but more than one in ten women had a mesh complication. Therefore, follow-up is vital to identify any longer-term potential beneﬁts and serious adverse eﬀects of mesh or graft reinforcement in vaginal prolapse surgery.
|Glazener CMA, Breeman S, Elders A et al.||The Lancet, Vol 389, Jan 28, 2017|
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