Release of chlorhexidine from titanium dental implant

Controlled release of chlorhexidine from a mesoporous silica-containing macroporous titanium dental implant prevents microbial biofilm formationK De Cremer, A Braem, E Gerits, K De Brucker, K Vandamme, JA Martens, J Michiels, J Vleugels, BPA Cammue, K Thevissen
Roughened surfaces are increasingly being used for dental implant applications as the enlarged contact area improves bone cell anchorage, thereby facilitating osseointegration. However, the additional surface area also entails a higher risk for the development of biofilm associated infections, an etiologic factor for many dental ailments, including peri-implantitis. To overcome this problem, we designed a dental implant composed of a porous titaniumsilica (Ti/SiO2) composite material and containing an internal reservoir that can be loaded with antimicrobial compounds.
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