Proton Pump Inhibitors and the Risk of Osseointegrated Dental Implant Failure

Proton pump inhibitors (PPIs) have a negative impact on bone accrual. Because osseointegration is influenced by bone metabolism, this study investigates the association between PPIs and the risk of osseointegrated implant failure. This retrospective cohort study included a total of 1,773 osseointegrated dental implants in 799 patients (133 implants in 58 PPIs users and 1,640 in 741 non‐users) who were treated at the East Coast Oral Surgery Clinic in Moncton, Canada, from January 2007 to September 2015.
The failure rates were 6.8% for people using PPIs compared to 3.2% for non‐users. Subjects using PPIs had a higher risk of dental implant failure (HR = 2.73; 95% CI = 1.10–6.78) compared to those who did not use the drugs. The findings suggest that treatment with PPIs may be associated with an increased risk of osseointegrated dental implant failure.
Author(s) Source
Wu X, Al-Abedalla K et al. Clinical Implant Dentistry and Related Research, 20 Oct 2016,
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