First-in-human prediction of chronic pain state using intracranial neural biomarkers

22 May 2023

Chronic pain syndromes are often refractory to treatment and cause substantial suffering and disability. Pain severity is often measured through subjective report, while objective biomarkers that may guide diagnosis and treatment are lacking.
Four individuals with refractory neuropathic pain were implanted with chronic intracranial electrodes in the anterior cingulate cortex and orbitofrontal cortex (OFC). We successfully predicted intraindividual chronic pain severity scores from neural activity with high sensitivity using machine learning methods.
Author(s)	Source
Shirvalkar P, Prosky J, Chin G et al.	nature neuroscience 22.05.2023
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