Phospholipid reduction treatment (PRT) for mitigated calcium absorption

The presence of phospholipids in the pericardial tissue play a key role in the calcification process of bioprostheses as their phosphate heads are potential binding sites for circulating calcium ions.

The PRT process removes phospholipids using Octanediol, a long chain alcohol that possesses a lipid-soluble tail to aid its solubility in phospholipids’s heads and a water-soluble head to allow removal by rinsing pericardial layers before valve manufacturing.

Patented by LivaNova. Used in Crown PRT heart valve.