Thrombocytes stop bleeding. They aggregate at the contact with collagen and the proteins from the implant surface and close the ruptured vessels.

Thrombocytes release messengers, to support crosslinking (thromboxan), to fibroblast building with PDGF(platelet derived growth factor).

Fibrin monomers crosslink. Adsorption of an implant materials iones and blood proteines (albumines, fibrinogen, fibronektin).