Sirolimus

Sirolimus (aka “rapamycin”), is used to coat coronary stents, prevent organ transplant rejection and treat a rare lung disease called lymphangioleiomyomatosis. It is immunsuppresiv. It inhibits activation of T cells and B cells by reducing their sensitivity to interleukin-2 (IL-2) through mTOR inhibition. It is produced by the bacterium Streptomyces hygroscopicus.