IMPLANT INFORMATION: Hard Tissue / Stem Cells

What … for? (Indications)
Bone marrow.
Most stem cell treatments are still in the research Phase.The primary roles of adult stem cells in a living organism are to maintain and repair the tissue in which they are found.		  
 stem cell scheme - pinstake
Numbers n/a
Times n/a
Risks (Contraindications) risks from the procedure
  • Graft-vs-host disease (GVHD), acute and chronic
  • Infection
  • Stem cell failure
  • Organ damage
  • New cancers
  • Biodistribution/ektopic grafting
  • Unwanted (de)differentiation
  • Pulmonary embolus/infarction
  • Death
long term: n/a
Failures n/a
Materials available Autologous stem cells (same Individuum)
Statistics n/a
Literature – Basic – Aubin JE: Bone stem cells. J Cell Biochem Suppl. 1998;30-31:73-82
– Bonnet D. Biology of human bone marrow stem cells. Clin Exp Med 2003;3: 140–9
– Cell Stem Cell
– Problems
– Amariglio N, Hirshberg A, Scheithauer BW, Cohen Y, Loewenthal R, Trakhtenbrot L, Paz N, Koren-Michowitz M, Waldman D, Leider-Trejo L. et al. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Medicine. 2009;6:0221–0231. doi: 10.1371/journal.pmed.1000029. [PMC free article] [PubMed] [Cross Ref]

– Sundin M, Orvell C, Rasmusson I, Sundberg B, Ringden O, Le Blanc K. Mesenchymal stem cells are susceptible to human herpesviruses, but viral DNA cannot be detected in the healthy seropositive individual. Bone Marrow Transplantation. 2006;37:1051–1059. doi: 10.1038/sj.bmt.1705368. [PubMed] [Cross Ref]

– Grigg A, Gibson R, Bardy P, Szer J. Acute portal vein thrombosis after autologous stem cell transplantation. Bone Marrow Transplantation. 1996;18:949–953. [PubMed]
– Science/Future n/a
Medical Societies (links) – International Society for Stem Cell Research
– American Society for Cell Biology (ASCB)
– Australasian Society for Stem Cell Research
– Danish Stem Cell Society
– German Society for Stem Cell Research
– International Cellular Medicine Society
– International Society for Cellular Therapy
– Stem Cell Society
– GSCN (German Stem Cell Network)
Register (links) – British Bone Marrow Registry – NHS Blood and Transplant
– Human Embryonic Stem Cell Registry
– Stem Cell Registry		 
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